Antioxidative and antidiabetic activity and phytochemicals, analysis of some selected Sudanese traditional medicinal plants.
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Date
2021
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Abstract
This study was conducted to evaluate the antioxidant and anti-diabetic properties of selected
traditional Sudanese medicinal plants (Cyperus rotundus, Nauclea latifolia, and Hibiscus
sabdariffa) using in vitro, ex vivo, and in silico experimental models. The crude extracts (ethyl
acetate, ethanol, and aqueous) were screened in vitro for their antioxidant activities using ferricreducing
antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and nitric oxide
radical (NO) scavenging activities, as well as their carbohydrate digesting enzyme inhibitory
activities for antidiabetic evaluation. Subsequently, the extracts were subjected to Gas
Chromatography-Mass Spectrometry (GC-MS) analysis to elucidate their possible bioactive
compounds. Additionally, ex vivo studies was conducted to investigate their capability to promote
muscle glucose uptake and suppress glucose absorption in the intestine as well as to analyze
antioxidative effects in iron–induced oxidative stress in hepatic tissue. Molecular docking was
carried out to determine the probable enzymes' inhibitory mode of action by ligands identified
through GC-MS. This study indicates that these traditional Sudanese medicinal plants have
remarkable antioxidant and antidiabetic activities, which may help to ameliorate oxidative stress
and diabetes. Therefore, these plants may be considered a natural source of bioactive compounds
beneficial for human health, particularly for managing diabetes and oxidative stress-related
metabolic disorders.
Description
Masters Degree. University of KwaZulu-Natal, Durban.