Browsing by Author "Dlamini, Sarah Alexandra."

Now showing 1 - 4 of 4

Adolescent girls and young women: key populations for HIV epidemic control.
(International AIDS Society., 2015) Dellar, Rachael Claire.; Dlamini, Sarah Alexandra.; Abdool Karim, Quarraisha.
Abstract available in pdf.
Assessing the implementation effectiveness and safety of 1% tenofovir gel provision through family planning services in KwaZulu-Natal, South Africa: study protocol for an open-label randomized controlled trial.
(BioMed Central., 2014) Mansoor, Leila Essop.; Abdool Karim, Quarraisha.; Mngadi, Kathryn Therese.; Dlamini, Sarah Alexandra.; Montague, Carl.; Nkomonde, Nelisiwe.; Mvandaba, Nomzamo.; Baxter, Cheryl.; Gengiah, Tanuja Narayansamy.; Samsunder, Natasha.; Dawood, Halima.; Grobler, Anna Christina.; Fröhlich, Janet Ann.; Abdool Karim, Salim Safurdeen.
Background: The Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004 trial demonstrated a 39% reduction in HIV infection, with a 54% HIV reduction in women who used tenofovir gel consistently. A confirmatory trial is expected to report results in early 2015. In the interim, we have a unique window of opportunity to prepare for and devise effective strategies for the future policy and programmatic scale-up of tenofovir gel provision. One approach is to integrate tenofovir gel provision into family planning (FP) services. The CAPRISA 008 implementation trial provides an opportunity to provide post-trial access to tenofovir gel while generating empiric evidence to assess whether integrating tenofovir gel provision into routine FP services can achieve similar levels of adherence as the CAPRISA 004 trial. Methods/design: This is a two-arm, open-label, randomized controlled non-inferiority trial. A maximum of 700 sexually active, HIV-uninfected women aged 18 years and older who previously participated in an antiretroviral prevention study will be enrolled from an urban and rural site in KwaZulu-Natal, South Africa. The anticipated study duration is 30 months, with active accrual requiring approximately 12 months (following which an open cohort will be maintained) and follow-up continuing for approximately 18 months. At each of the two sites, eligible participants will be randomly assigned to receive tenofovir gel through either FP services (intervention arm) or through the CAPRISA research clinics (control arm). As part of the study intervention, a quality improvement approach will be used to assist the FP services to expand their current services to include tenofovir gel provision. Discussion: This protocol aims to address an important implementation question on whether FP services are able to effectively incorporate tenofovir gel provision for this at-risk group of women in South Africa. Provision of tenofovir gel to the women from the CAPRISA 004 trial meets the ethical obligation for post-trial access, and helps identify a potential avenue for future scale-up of microbicides within the public health system of South Africa. Trial registration: This trial was registered with the South Africa Department of Health (reference: DOH-27-0812-4129) and ClinicalTrials.gov (reference: NCT01691768) on 05 July 2012.
Randomized cross-sectional study to compare HIV-1 specific antibody and cytokine concentrations in female genital secretions obtained by menstrual cup and cervicovaginal lavage.
(Public Library of Science., 2015) Archary, Derseree.; Liebenberg, Lenine Julie.; Werner, Lise.; Tulsi, Sahil.; Majola, Nelisile.; Naicker, Nivashnee.; Dlamini, Sarah Alexandra.; Hope, Thomas J.; Samsunder, Natasha.; Abdool Karim, Salim Safurdeen.; Morris, Lynn.; Passmore, Jo-Ann Shelley.; Garrett, Nigel Joel.
Abstract available in pdf.
Social context of adherence in an open-label 1% tenofovir gel trial : gender dynamics and disclosure in KwaZulu-Natal, South Africa.
(Springer., 2016) MacQueen, Kathleen M.; Dlamini, Sarah Alexandra.; Perry, Brian.; Okumu, Eunice.; Sortijas, Steve.; Singh, Chitra.; Pillay, Diantha.; Majors, Alesha.; Jerome, Sonja.; Watson, Sharon.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Mansoor, Leila Essop.
Abstract available in PDF file.