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Browsing by Author "Horsburgh, Charles Robert."

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    Adherence in the treatment of patients with extensively drug-resistant tuberculosis and HIV in South Africa: a prospective cohort study.
    (Lippincott Williams & Wilkins., 2014) O'Donnell, Max Roe.; Wolf, Allison.; Werner, Lise.; Horsburgh, Charles Robert.; Padayatchi, Nesri.
    Abstract available in pdf.
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    Primary capreomycin resistance is common and associated with early mortality in patients with extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa.
    (Wolters Kluwer., 2015) O’Donnell, Max Roe.; Pillay, Melendhran.; Pillay, Manormoney.; Werner, Lise.; Master, Iqbal.; Wolf, Allison.; Mathema, Barun.; Coovadia, Yacoob Mahomed.; Mlisana, Koleka Patience.; Horsburgh, Charles Robert.; Padayatchi, Nesri.
    Abstract available in pdf.
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    Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection.
    (U.S. National Center for Infectious Diseases., 2013) O'Donnell, Max Roe.; Padayatchi, Nesri.; Kvasnovsky, Charlotte.; Werner, Lise.; Master, Iqbal.; Horsburgh, Charles Robert.
    High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. We report treatment outcomes for adult XDR TB patients in KwaZulu-Natal Province, South Africa. Initial data were obtained retrospectively, and outcomes were obtained prospectively during 24 months of treatment. A total of 114 XDR TB patients were treated (median 6 drugs, range 3–9 drugs); 82 (73%) were HIV positive and 50 (61%) were receiving antiretroviral therapy. After receiving treatment for 24 months, 48 (42%) of 114 patients died, 25 (22%) were cured or successfully completed treatment, 19 (17%) defaulted from the study, and 22 (19%) showed treatment failure. A higher number of deaths occurred among HIV-positive patients not receiving antiretroviral therapy and among patients who did not show sputum culture conversion. Culture conversion was a major predictor of survival but was poorly predictive (51%) of successful treatment outcome.