Repository logo

Browsing by Author "Hunt, Gillian."

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis.
    (Elsevier., 2018) Gupta, Ravindra K.; Gregson, John.; Parkin, Neil.; Haile-Selassie, Hiwot.; Tanuri, Amilcar.; Andrade Forero, Liliana.; Kaleebu, Pontiano.; Watera, Christine.; Aghokeng, Avelin.; Mutenda, Nicholus.; Dzangare, Janet.; Hone, San.; Hang, Zaw Zaw.; Garcia, Judith.; Garcia, Judith.; Garcia, Zully.; Marchorro, Paola.; Beteta, Enrique.; Giron, Amalia.; Hamers, Raph.; Inzaule, Seth.; Frenkel, Lisa M.; Chung, Michael H.; De Oliveira, Tulio De Paiva Nazareth Andrade.; Pillay, Deenan.; Naidoo, Kogieleum.; Kharsany, Ayesha Bibi Mahomed.; Kugathasan, Ruthiran.; Cutino, Teresa.; Hunt, Gillian.; Avila Rios, Santiago.; Doherty, Meg.; Jordan, Michael R.; Bertagnolio, Silvia.
    Abstract available in pdf.
  • Thumbnail Image
    Item
    Moderate-to-high levels of pretreatment HIV drug resistance in KwaZulu-Natal Province, South Africa.
    (Mary Ann Liebert., 2019) Chimukangara, Benjamin.; Naidoo, Kogieleum.; Rhee, Soo-Yon.; Manasa, Justen.; Gräf, Tiago.; Lewis, Lara.; Cawood, Cherie.; Khanyile, David.; Diallo, Karidia.; Ayalew, Kassahun A.; Shafer, Robert W.; Hunt, Gillian.; Pillay, Deenan.; De Oliveira, Tulio De Paiva Nazareth Andrade.; Abdool Karim, Salim Safurdeen.; Lessells, Richard John.; Kharsany, Ayesha Bibi Mahomed.
    Abstract available in PDF.
  • Thumbnail Image
    Item
    Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.
    (Oxford University Press., 2014) Wei, Xierong.; Hunt, Gillian.; Abdool Karim, Salim Safurdeen.; Naranbhai, Vivek.; Sibeko, Sengeziwe.; Abdool Karim, Quarraisha.; Li, Jin-fen.; Kashuba, Angela D. M.; Werner, Lise.; Passmore, Jo-Ann Shelley.; Morris, Lynn.; Heneine, Walid.; Johnson, Jeffrey A.
    The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated that vaginally applied tenofovir gel is a promising intervention for protecting women from sexually acquiring human immunodeficiency virus (HIV). However, the potential for emergence of tenofovir resistance remains a concern in women who seroconvert while using the gel despite the lack of plasma virus resistance as assessed by population sequencing during the trial. We applied highly sensitive polymerase chain reaction-based assays to screen for tenofovir resistance in plasma and vaginal swab specimens. The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion.