Browsing by Author "Kashuba, Angela D. M."
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Item Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women.(Elsevier., 2011) Abdool Karim, Salim Safurdeen.; Kashuba, Angela D. M.; Werner, Lise.; Abdool Karim, Quarraisha.No abstract available.Item Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.(Nature Publishing Group., 2018) McKinnon, Lyle R.; Liebenberg, Lenine Julie.; Yende-Zuma, Fortunate Nonhlanhla.; Archary, Derseree.; Ngcapu, Sinaye.; Sivro, Aida.; Nagelkerke, Nico.; Garcia Lerma, Gerardo.; Kashuba, Angela D. M.; Masson, Lindi.; Mansoor, Leila Essop.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Passmore, Jo-Ann Shelley.Abstract available in pdf.Item Genital tenofovir concentrations correlate with protection against HIV infection in the CAPRISA 004 trial: importance of adherence for microbicide effectiveness.(Wolters Kluwer., 2015) Kashuba, Angela D. M.; Gengiah, Tanuja Narayansamy.; Werner, Lise.; Yang, Kuo-Hsiung.; White, Nicole R.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.Abstract available in pdf.Item Measuring adherence by visual inspection of returned empty gel applicators in the CAPRISA 004 microbicide trial.(Springer., 2014) Gengiah, Tanuja Narayansamy.; Mansoor, Leila Essop.; Upfold, Michele.; Naidoo, Anushka.; Yende-Zuma, Fortunate Nonhlanhla.; Kashuba, Angela D. M.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.Abstract not available in pdf.Item Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.(Oxford University Press., 2014) Wei, Xierong.; Hunt, Gillian.; Abdool Karim, Salim Safurdeen.; Naranbhai, Vivek.; Sibeko, Sengeziwe.; Abdool Karim, Quarraisha.; Li, Jin-fen.; Kashuba, Angela D. M.; Werner, Lise.; Passmore, Jo-Ann Shelley.; Morris, Lynn.; Heneine, Walid.; Johnson, Jeffrey A.The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated that vaginally applied tenofovir gel is a promising intervention for protecting women from sexually acquiring human immunodeficiency virus (HIV). However, the potential for emergence of tenofovir resistance remains a concern in women who seroconvert while using the gel despite the lack of plasma virus resistance as assessed by population sequencing during the trial. We applied highly sensitive polymerase chain reaction-based assays to screen for tenofovir resistance in plasma and vaginal swab specimens. The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion.Item Tenofovir gel for the prevention of herpes simplex virus type 2 infection.(Massachusetts Medical Society., 2015) Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Kharsany, Ayesha Bibi Mahomed.; Baxter, Cheryl.; Grobler, Anna Christina.; Werner, Lise.; Kashuba, Angela D. M.; Mansoor, Leila Essop.; Samsunder, Natasha.; Mindel, Adrian.; Gengiah, Tanuja Narayansamy.Abstract available in pdf.