Browsing by Author "Master, Iqbal."

Now showing 1 - 9 of 9

Association between health systems performance and treatment outcomes in patients co-infected with MDR-TB and HIV in KwaZulu-Natal, South Africa: implications for TB programmes.
(Public Library of Science., 2014) Loveday, Marian Patricia.; Padayatchi, Nesri.; Wallengren, Kristina.; Roberts, Jacquelin.; Brust, James C. M.; Ngozo, Jacqueline.; Master, Iqbal.; Voce, Anna Silvia.
Objective: To improve the treatment of MDR-TB and HIV co-infected patients, we investigated the relationship between health system performance and patient treatment outcomes at 4 decentralised MDR-TB sites. Methods: In this mixed methods case study which included prospective comparative data, we measured health system performance using a framework of domains comprising key health service components. Using Pearson Product Moment Correlation coefficients we quantified the direction and magnitude of the association between health system performance and MDR-TB treatment outcomes. Qualitative data from participant observation and interviews analysed using systematic text condensation (STC) complemented our quantitative findings. Findings: We found significant differences in treatment outcomes across the sites with successful outcomes varying from 72% at Site 1 to 52% at Site 4 (p<0.01). Health systems performance scores also varied considerably across the sites. Our findings suggest there is a correlation between treatment outcomes and overall health system performance which is significant (r = 0.99, p<0.01), with Site 1 having the highest number of successful treatment outcomes and the highest health system performance. Although the 'integration' domain, which measured integration of MDR-TB services into existing services appeared to have the strongest association with successful treatment outcomes (r = 0.99, p<0.01), qualitative data indicated that the 'context' domain influenced the other domains. Conclusion: We suggest that there is an association between treatment outcomes and health system performance. The chance of treatment success is greater if decentralised MDR-TB services are integrated into existing services. To optimise successful treatment outcomes, regular monitoring and support are needed at a district, facility and individual level to ensure the local context is supportive of new programmes and implementation is according to guidelines.
Cellular therapy in Tuberculosis.
(Elsevier., 2015) Parida, Shreemanta K.; Madansein, Rajhmun.; Singh, Nalini.; Padayatchi, Nesri.; Master, Iqbal.; Naidu, Kantharuben.; Zumla, Alimuddin.; Maeurer, Markus.
Abstract available in pdf.
Clofazimine in the treatment of extensively drug-resistant tuberculosis with HIV coinfection in South Africa: a retrospective cohort study.
(Oxford University Press., 2014) Padayatchi, Nesri.; Gopal, Murali.; Naidoo, Rowena.; Werner, Lise.; Naidoo, Kimesh.; Master, Iqbal.; O'Donnell, Max Roe.
Abstract available in pdf.
Community-based care vs. centralised hospitalisation for MDR-TB patients, KwaZulu-Natal, South Africa.
(International Union Against Tuberculosis and Lung Disease., 2015) Loveday, Marian Patricia.; Wallengren, Kristina.; Brust, James C. M.; Roberts, Jacquelin.; Voce, Anna Silvia.; Margot, Bruce.; Ngozo, Jacqueline.; Master, Iqbal.; Cassell, Gail H.; Padayatchi, Nesri.
Abstract available in pdf.
Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in KwaZulu-Natal, South Africa.
(International Union against Tuberculosis and Lung Disease., 2012) Loveday, Marian Patricia.; Wallengren, Kristina.; Voce, Anna Silvia.; Margot, Bruce.; Reddy, T.; Master, Iqbal.; Brust, James C. M.; Chaiyachati, K.; Padayatchi, Nesri.
Setting—In KwaZulu-Natal, South Africa, a TB and HIV endemic setting, prolonged hospitalisation for the treatment of the growing number of MDR-TB patients is not possible or effective. Objective—We compared early treatment outcomes in patients with MDR-TB, with and without HIV co infection, at a central, urban, referral hospital with four decentralised rural sites. Design—This is an operational, prospective cohort study of patients between 1 July 2008 to 30 November 2009, where culture conversion, time-to-culture-conversion, survival and predictors of these outcomes were analysed. Results—Of the 860 patients with MDR-TB, 419 were at the decentralised sites and 441 at the central hospital. Overall, 71% were HIV co-infected.
MDR-TB patients in KwaZulu-Natal, South Africa: cost-effectiveness of 5 models of care.
(Public Library of Science., 2018) Loveday, Marian Patricia.; Wallengren, Kristina.; Reddy, Tarylee.; Besada, Donela.; Brust, James C. M.; Voce, Anna Silvia.; Desai, Harsha.; Ngozo, Jacqueline.; Radebe, Zanele.; Master, Iqbal.; Padayatchi, Nesri.; Daviaud, Emmanuelle.
Abstract available in pdf.
Primary capreomycin resistance is common and associated with early mortality in patients with extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa.
(Wolters Kluwer., 2015) O’Donnell, Max Roe.; Pillay, Melendhran.; Pillay, Manormoney.; Werner, Lise.; Master, Iqbal.; Wolf, Allison.; Mathema, Barun.; Coovadia, Yacoob Mahomed.; Mlisana, Koleka Patience.; Horsburgh, Charles Robert.; Padayatchi, Nesri.
Abstract available in pdf.
Surgical treatment of complications of pulmonary tuberculosis, including drug-resistant tuberculosis.
(Elsevier., 2015) Madansein, Rajhmun.; Parida, Shreemanta.; Padayatchi, Nesri.; Singh, Nalini.; Master, Iqbal.; Naidu, Kantharuben.; Zumla, Alimuddin.; Maeurer, Markus.
Abstract available in pdf.
Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection.
(U.S. National Center for Infectious Diseases., 2013) O'Donnell, Max Roe.; Padayatchi, Nesri.; Kvasnovsky, Charlotte.; Werner, Lise.; Master, Iqbal.; Horsburgh, Charles Robert.
High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. We report treatment outcomes for adult XDR TB patients in KwaZulu-Natal Province, South Africa. Initial data were obtained retrospectively, and outcomes were obtained prospectively during 24 months of treatment. A total of 114 XDR TB patients were treated (median 6 drugs, range 3–9 drugs); 82 (73%) were HIV positive and 50 (61%) were receiving antiretroviral therapy. After receiving treatment for 24 months, 48 (42%) of 114 patients died, 25 (22%) were cured or successfully completed treatment, 19 (17%) defaulted from the study, and 22 (19%) showed treatment failure. A higher number of deaths occurred among HIV-positive patients not receiving antiretroviral therapy and among patients who did not show sputum culture conversion. Culture conversion was a major predictor of survival but was poorly predictive (51%) of successful treatment outcome.