Browsing by Author "McCormack, Sheena."

Now showing 1 - 3 of 3

Challenges in HIV-prevention microbicide research.
(American Association for the Advancement of Science., 2008) Harrison, Polly.; Mellors, John W.; Richardson, Barbra Ann.; Masse, Benoit.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Cates, Ward.; Coletti, Anne S.; Derbyshire, Janet.; Dorflinger, Laneta J.; Feldblum, Paul J.; Gabelnick, Henry.; Halpern, Vera Grigorieva.; Jespers, Vicky.; Kharsany, Ayesha Bibi Mahomed.; McCormack, Sheena.; Nunn, Andrew.; McGowan, Ian M.; Omar, Rabeea F.; Padian, Nancy S.; Pedneault, Louise.; Robbiani, Melissa Pope.; Sailer, James.; Taylor, Douglas.; Tolley, Elizabeth E.; Van Damme, Lut.; Vermund, Sten H.; van de Wijgert, Janneke.
No abstract available.
Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis.
(Public Library of Science., 2015) Morrison, Charles S.; Chen, Pai-Lien.; Kwok, Cynthia.; Baeten, Jared M.; Brown, Joelle.; Crook, Angela M.; Van Damme, Lut.; Delany-Moretlwe, Sinead.; Francis, Suzanna C.; Friedland, Barbara A.; Hayes, Richard J.; Heffron, Renee.; Kapiga, Saidi.; Abdool Karim, Quarraisha.; Karpoff, Stephanie.; Kaul, Rupert.; McClelland, Raymond Scott.; McCormack, Sheena.; McGrath, Nuala.; Myer, Landon.; Rees, Helen.; van der Straten, Ariane.; Watson-Jones, Deborah.; van de Wijgert, Janneke.; Stalter, Randy.; Low, Nicola.
Abstract available in pdf.
Microbicide clinical trial adherence: insights for introduction.
(BioMed Central., 2012) Woodsong, Cynthia.; MacQueen, Kathleen M.; Amico, Kathy Rivet.; Friedland, Barbara A.; Gafos, Mitzy.; Mansoor, Leila Essop.; Tolley, Elizabeth E.; McCormack, Sheena.
After two decades of microbicide clinical trials it remains uncertain if vaginally- delivered products will be clearly shown to reduce the risk of HIV infection in women and girls. Furthermore, a microbicide product with demonstrated clinical efficacy must be used correctly and consistently if it is to prevent infection. Information on adherence that can be gleaned from microbicide trials is relevant for future microbicide safety and efficacy trials, pre-licensure implementation trials, Phase IV post-marketing research, and microbicide introduction and delivery. Drawing primarily from data and experience that has emerged from the large-scale microbicide efficacy trials completed to-date, the paper identifies six broad areas of adherence lessons learned: (1) Adherence measurement in clinical trials, (2) Comprehension of use instructions/Instructions for use, (3) Unknown efficacy and its effect on adherence/Messages regarding effectiveness, (4) Partner influence on use, (5) Retention and continuation and (6) Generalizability of trial participants’ adherence behavior. Each is discussed, with examples provided from microbicide trials. For each of these adherence topics, recommendations are provided for using trial findings to prepare for future microbicide safety and efficacy trials, Phase IV post-marketing research, and microbicide introduction and delivery programs.