Browsing by Author "Mgodi, Nyaradzo."

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Bacterial vaginosis and the risk of trichomonas vaginalis acquisition among HIV-1 negative women.
(American Sexually Transmitted Diseases Association., 2014) Balkus, Jennifer E.; Richardson, Barbra Ann.; Rabe, Lorna K.; Taha, Taha E.; Mgodi, Nyaradzo.; Kasaro, Margaret Phiri.; Ramjee, Gita.; Hoffman, Irving F.; Abdool Karim, Salim Safurdeen.
Background: The vaginal microbiota may play a role in mediating susceptibility to sexually transmitted infections, including Trichomonas vaginalis (TV). Methods: Data were analyzed from HIV-1-seronegative women participating in HIV Prevention Trials Network Protocol 035. At quarterly visits for up to 30 months, participants completed structured interviews and specimens were collected for genital tract infection testing. T. vaginalis was detected by saline microscopy. Bacterial vaginosis (BV) was characterized by Gram stain using the Nugent score (BV = 7Y10; intermediate = 4Y6; normal = 0Y3 [reference group]). Cox proportional hazards models stratified by study site were used to assess the association between Nugent score category at the prior quarterly visit and TV acquisition. Results: In this secondary analysis, 2920 participants from Malawi, South Africa, United States, Zambia, and Zimbabwe contributed 16,259 follow-up visits. Bacterial vaginosis was detected at 5680 (35%) visits,and TV was detected at 400 (2.5%) visits. Adjusting for age, marital status, hormonal contraceptive use, unprotected sex in the last week and TV at baseline, intermediate Nugent score, and BVat the prior visit were associated with an increased risk of TV (intermediate score: adjusted hazard ratio [aHR], 1.73; 95% confidence interval [CI], 1.21Y2.19; BV: aHR, 2.40; 95% CI, 1.92Y3.00). Sensitivity analyses excluding 211 participants with TV at baseline were similar to those from the full study population (intermediate score: aHR, 1.54; 95% CI, 1.10Y2.14; BV: aHR, 2.23; 95% CI, 1.75Y2.84). Conclusions: Women with a Nugent score higher than 3 were at an increased risk for acquiring TV. If this relationship is causal, interventions that improve the vaginal microbiota could contribute to reductions in TV incidence.
Characteristics of women enrolled into a randomized clinical trial of dapivirine vaginal ring for HIV-1 prevention.
(Public Library of Science., 2015) Palanee-Phillips, Thesla.; Schwartz, Katie.; Brown, Elizabeth R.; Govender, Vaneshree.; Mgodi, Nyaradzo.; Kiweewa, Flavia Matovu.; Nair, Gonasagrie.; Mhlanga, Felix.; Siva, Samantha.; Bekker, Linda-Gail.; Jeenarain, Nitesha.; Gaffoor, Zakir.; Martinson, Francis E.; Makanani, Bonus.; Naidoo, Sarita.; Pather, Arendevi.; Phillip, Jessica Lyn.; Husnik, Marla J.; van der Straten, Ariane.; Soto-Torres, Lydia.; Baeten, Jared M.
Abstract available in pdf.
HPTN 035 phase II/IIb randomised safety and effectiveness study of the vaginal microbicides BufferGel and 0.5% PRO 2000 for the prevention of sexually transmitted infections in women.
(BMJ., 2014) Guffey, M Bradford.; Richardson, Barbra Ann.; Husnik, Marla.; Makanani, Bonus.; Chilongozi, David.; Yu, Elmer.; Ramjee, Gita.; Mgodi, Nyaradzo.; Gomez, Kailazarid.; Hillier, Sharon Louise.; Abdool Karim, Salim Safurdeen.
Abstract available in pdf.
Oral and injectable contraceptive use and HIV acquisition risk among women in four African countries : a secondary analysis of data from a microbicide trial.
(Elsevier., 2016) Balkus, Jennifer E.; Brown, Elizabeth R.; Hillier, Sharon Louise.; Coletti, Anne S.; Ramjee, Gita.; Mgodi, Nyaradzo.; Makanani, Bonus.; Reid, Cheri.; Martinson, Francis E.; Soto-Torres, Lydia.; Abdool Karim, Salim Safurdeen.; Chirenje, Zvavahera Mike.
Abstract available in pdf.
Tenofovir-based preexposure prophylaxis for HIV infection among African women.
(Massachusetts Medical Society., 2015) Marrazzo, Jeanne M.; Ramjee, Gita.; Richardson, Barbra Ann.; Gomez, Kailazarid.; Mgodi, Nyaradzo.; Nair, Gonasagrie.; Palanee, Thesla.; Nakabiito, Clemensia.; van der Straten, Ariane.; Noguchi, Lisa M.; Hendrix, Craig W.; Dai, James Y.; Ganesh, Shayhana.; Mkhize, Baningi.; Taljaard, Marthinette.; Parikh, Urvi M.; Piper, Jeanna M.; Mâsse, Benoît.; Grossman, Cynthia.; Rooney, James.; Schwartz, Jill L.; Watts, Heather D.; Marzinke, Mark Albert.; Hillier, Sharon Louise.; McGowan, Ian M.; Chirenje, Zvavahera Mike.
Abstract available in pdf.