Browsing by Author "Upshur, Ross Edward Grant."

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Addressing ethical, social, and cultural issues in global health research.
(Plos., 2013) Lavery, James V.; Green, Shane K.; Bandewar, Sunita V. S.; Bhan, Anant.; Daar, Abdallah S.; Emerson, Claudia I.; Masum, Hassan.; Randazzo, Filippo M.; Singh, Jerome Amir.; Upshur, Ross Edward Grant.; Singer, Peter A.
The purpose of this paper is to encourage reflection among the global health research community and the research ethics community about how a wide range of ethical, social, and cultural (ESC) influences on the conduct, success, and impact of global health research can best be addressed by consultation services in research ethics (CSRE). We draw on lessons we have learned during our experiences with the ESC Program of the Grand Challenges in Global Health initiative to propose key features of CSRE that may prove useful for those designing or implementing similar programs.
Grand challenges in global health : community engagement in research in developing countries.
(Plos., 2007) Tindana, Paulina O.; Singh, Jerome Amir.; Tracy, C. Shawn.; Upshur, Ross Edward Grant.; Daar, Abdallah S.; Singer, Peter A.; Fröhlich, Janet Ann.; Lavery, James V.
The authors argue that there have been few systematic attempts to determine the effectiveness of community engagement in research.
Grand challenges in global health : engaging civil society organizations in biomedical research in developing countries.
(Plos., 2007) Bhan, Anant.; Singh, Jerome Amir.; Upshur, Ross Edward Grant.; Singer, Peter A.; Daar, Abdallah S.
The authors discuss the different types of civil society organizations, their role in biomedical research, and the advantages and challenges of working with them.
Grand challenges in global health : ethical, social, and cultural issues based on key informant perspectives.
(Plos., 2007) Berndtson, Kathryn.; Daid, Tina.; Tracy, C. Shawn.; Bhan, Anant.; Cohen, Emma R. M.; Upshur, Ross Edward Grant.; Singh, Jerome Amir.; Lavery, James V.; Singer, Peter A.
The authors interviewed key informants from the developing world and the Grand Challenges investigators to explore their ethical, social, and cultural concerns about the program.
Grand challenges in global health : the ethical, social and cultural program.
(Plos., 2007) Singer, Peter A.; Taylor, Andrew D.; Daar, Abdallah S.; Upshur, Ross Edward Grant.; Singh, Jerome Amir.; Lavery, James V.
The Grand Challenges initiative has 44 projects worldwide aimed at addressing diseases of the poor. What are the ethical, social, and cultural issues that the initiative faces?
Innovations in research ethics governance in humanitarian settings.
(BioMed Central., 2015) Schopper, Doris.; Dawson, Angus.; Upshur, Ross Edward Grant.; Ahmad, Aasim.; Jesani, Amar.; Ravinetto, Raffaella.; Segelid, Michael J.; Sheel, Sunita.; Singh, Jerome Amir.
Abstract available in pdf.
Organ donation, discrimination after death, anti-vaccination sentiments, and tuberculosis management.
(Springer Verlag., 2012) Coggon, John.; Madden, Bill.; Cockburn, Tina.; Stewart, Cameron.; Singh, Jerome Amir.; Bhan, Anant.; Upshur, Ross Edward Grant.; Richards, Bernadette.
No abstract available.
Research ethics governance in times of Ebola.
(Oxford University Press., 2017) Schopper, Doris.; Ravinetto, Raffaella.; Schwartz, Lisa.; Kamaara, Eunice.; Sheel, Sunita.; Segelid, Michael J.; Ahmad, Aasim.; Dawson, Angus.; Singh, Jerome Amir.; Jesani, Amar.; Upshur, Ross Edward Grant.
Abstract available in pdf.
XDR-TB in South Africa : no time for denial or complacency.
(Plos., 2007) Singh, Jerome Amir.; Upshur, Ross Edward Grant.; Padayatchi, Nesri.
On September 1, 2006, the World Health Organisation (WHO) announced that a deadly new strain of extensively drug-resistant tuberculosis (XDR-TB) had been detected in Tugela Ferry (Figure 1), a rural town in the South African province of KwaZulu-Natal (KZN) [1], the epicentre of South Africa’s HIV/AIDS epidemic. Of the 544 patients studied in the area in 2005, 221 had multi-drug-resistant tuberculosis (MDR-TB), that is, Mycobacterium tuberculosis that is resistant to at least rifampicin and isoniazid. Of these 221 cases, 53 were identified as XDR-TB (see Table 1 and [2]), i.e., MDR-TB plus resistance to at least three of the six classes of second-line agents [3]. This reportedly represents almost one-sixth of all known XDR-TB cases reported worldwide [4]. Of the 53, 44 were tested for HIV and all were HIV infected. The median survival from the time of sputum specimen collection was 16 days for 52 of the 53 infected individuals, including six health workers and those reportedly taking antiretrovirals [2]. Such a fatality rate for XDR-TB, especially within such a relatively short period of time, is unprecedented anywhere in the world.