Immunology
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Impact of Duffy Antigen Receptor for Chemokines (DARC)-null linked Neutropenia on Neutrophil and Natural Killer cell Function in HIV-1 Infection.
(2018)Sub-Saharan Africa carries a disproportionate burden of the HIV-1 epidemic. The Duffy Antigen Receptor for Chemokines (DARC)-null polymorphism is a predictor of ethnic neutropenia which commonly occurs in persons of African ... -
Molecular mechanisms of CD8+ T cell mediated control of HIV-1 infection in peripheral blood and lymphoid tissues.
(2019)Naturally induced CD8+ T cells do not clear human immunodeficiency virus (HIV) infection, partly because the virus rapidly escapes CD8+ T cell responses and the effector cells are excluded from HIV reservoirs sites. However, ... -
T follicular helper cell dynamics during acute HIV-1 subtype C infection and relevance for T-helper cell-dependent responses.
(2018)Abstract available in pdf. -
Immunological effects of asymptomatic vibrio cholerae, salmonella enterica serovar typhi and entamoeba histolytica enteric pathogens during HIV infection and exposure.
(2017)Background Asymptomatic infection by enteric pathogens has been attributed to causing several outbreaks in the world. Common pathogens in this category are Vibrio cholerae, Salmonella typhi and Entamoeba histolytica ... -
Characterizing the role of CD4+ T cell immunoregulatory networks in peripheral blood and lymphoid tissue during HIV-1 clade C infection.
(2018)HIV eradication efforts have been unsuccessful due to virus persistence in cellular and tissue reservoirs. Recent evidence suggests that germinal centers (GCs) within lymph nodes (LN) contain a novel subset of regulatory ... -
Sex differences in the Kinetics of immune reconstitution under antiretroviral therapy.
(2017)The human immunodeficiency virus type 1 (HIV-1) remains a global health threat and is increasingly becoming a female epidemic due to gender inequalities. The introduction of antiretroviral therapy (ART) has greatly increased ... -
Development and optimization of real-time PCR assays to detect anti-microbial immune factors and their response to type I and II interferons.
(2016)Abstract available in PDF file. -
Protective HLA class I alleles : investigation of viral control and lack of control in chronic HIV-1 subtype C infection.
(2015)Abstract available in PDF file. -
Analysis of viral inhibitory activity of cytotoxic T. Lymphocytes targeting identical epitopes restricted by different class 1 HLA alleles from the same HLA supertype.
(2015)Human leukocyte antigen (HLA) polymorphism and the genetic diversity of human immunodeficiency virus (HIV) are the major obstacles for designing an effective HIV Cytotoxic T Lymphocytes (CTLs) based vaccine. Interestingly, ... -
Patterns and features of HIV-1 specific CD8+ T-cell responses during acute HIV-1 infection and their association with viral control.
(2015)Evidence suggests that CD8+ T-‐cells play a major role in the control of HIV-‐1 viremia and apply significant immune pressure on HIV-‐1 replication. However, the presence of virus-‐specific ... -
Mapping immunodominant patterns and HLA class II restriction characteristics of HIV-specific CD4+ T cell responses in acute and chronic HIV-1 subtype C infection.
(2014)Increasing evidence suggests that virus-specific CD4+ T cells contribute to immune-mediated control of HIV-1 infection. However, precise details of CD4+ T cell contribution to immune protection against HIV have not been ...
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