• Login
    View Item 
    •   ResearchSpace Home
    • Caprisa (Centre for the Aids programme of research in South Africa)
    • Research papers (Caprisa)
    • View Item
    •   ResearchSpace Home
    • Caprisa (Centre for the Aids programme of research in South Africa)
    • Research papers (Caprisa)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT trial.

    Thumbnail
    View/Open
    Padayatchi_Nesri_2014.pdf (957.9Kb)
    Date
    2014
    Author
    Padayatchi, Nesri.
    Naidoo, Kogieleum.
    Grobler, Anna Christina.
    Abdool Karim, Salim Safurdeen.
    Friedland, Gerald H.
    Metadata
    Show full item record
    Abstract
    BACKGROUND: The therapeutic effects of antiretroviral treatment (ART) in patients with multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus (HIV) infection have not been established. Objective : To assess therapeutic outcomes of integrating ART with treatment for MDR-TB. Design: A subgroup of MDR-TB patients from a randomised controlled trial, the SAPiT (Starting Antiretroviral Therapy at Three Points in Tuberculosis) study, conducted in an out-patient clinic in Durban, South Africa, from 2008 to 2012. Methods : Clinical outcomes at 18 months were compared in patients randomised to receive ART within 12 weeks of initiating standard first-line anti-tuberculosis treatment with those who commenced ART after completing anti-tuberculosis treatment. Results : Mycobacterium tuberculosis drug susceptibility results were available in 489 (76%) of 642 SAPiT patients: 23 had MDR-TB, 14 in the integrated treatment arm and 9 in the sequential treatment arm. At 18 months, the mortality rate was 11.9/100 person-years (py; 95%CI 1.4–42.8) in the combined integrated treatment arm and 56.0/100 py (95%CI 18.2–130.8) in the sequential treatment arm (hazard ratio adjusted for baseline CD4 count and whether MDR-TB treatment was initiated: 0.14; 95%CI 0.02–0.94, P " 0.04). Conclusion: Despite the small sample size, the 86% reduction in mortality due to early initiation of ART in MDR-TB patients was statistically significant.
    URI
    http://dx.doi.org/10.5588/ijtld.13.0627
    http://hdl.handle.net/10413/13345
    Collections
    • Research papers (Caprisa) [456]

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisorsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisorsType

    My Account

    LoginRegister

    DSpace software copyright © 2002-2013  Duraspace
    Contact Us | Send Feedback
    Theme by 
    @mire NV