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dc.contributor.advisorRasool, Mahomed Noor.
dc.creatorBhatta, Aabash Dev.
dc.date.accessioned2017-11-13T13:19:36Z
dc.date.available2017-11-13T13:19:36Z
dc.date.created2016
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10413/14794
dc.descriptionMaster of Medical Science in Orthopaedics. University of KwaZulu-Natal, Durban 2016.en_US
dc.description.abstractOsteogenesis imperfecta (OI), or brittle bone disease, is a debilitating genetic disorder of connective tissue which is characterized by reduced skeletal mass and bone fragility. OI results from mutations in genes encoding for type I collagen. Since collagen is the major structural protein in bone, ligaments, tendons, skin, sclera and dentin, clinical manifestations of OI include fragile bones with skeletal deformity, blue sclerae, hearing loss, and opalescent teeth. The orthopedic manifestations of OI are diverse. Most OI patients present with long bone fractures, joint contractures, foot deformities and bowing of long bones. Successful treatment of this condition is potentially challenging and requires a multidisciplinary approach. Surgical intervention is cumbersome because of growing bone, poor bone quality and soft tissue contractures. Advances in the medical management of OI have shown promising increases in bone mineral density and decreases in fracture incidence.en_US
dc.language.isoen_ZAen_US
dc.subject.otherOsteogenesis imperfecta.en_US
dc.subject.otherDebilitating genetic disorder.en_US
dc.subject.otherBone fragility.en_US
dc.subject.otherBittle bone disease.en_US
dc.titleThe orthopaedic manifestations of osteogenesis imperfecta : a collective review.en_US
dc.typeThesisen_US


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