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The role of leptin in HIV associated pre-eclampsia.
(2013)
HIV and hypertensive disorders in pregnancy, in particular pre-eclampsia, are the main causes of maternal mortality in South Africa. In HIV associated pre-eclampsia, it is biologically plausible that the immune activation ...
The effect of vitamin B-6 deficiency on copper, zinc and iron balance in the rat.
(1988)
In order to address the contradictory reports on the rat trace element
status during a vitamin 8-6 deficiency, Zn, Cu and Fe balance was
assessed over 8 weeks in 3 groups of young male rats.
Group 1 was the control group ...
The role of trophoblast cells in HIV-1 passage across the placenta.
(2015)
Background
The combination of pre-eclampsia and human immunodeficiency virus (HIV) remains a major obstetric dilemma in South Africa and, consequently, mother to child transmission of HIV remains a burden in our community.
The ...
Immunohistochemical and ultrastructural evaluation of the pathology and aetiopathogenesis of keloid formation.
(2013)
Introduction
Keloids are formed by the excessive production of scar tissue, which extends beyond the margins
of the original injury, often resulting in lesions of grotesque dimensions.
Keloids present a major dilemma ...
The optimisation of a preeclampsia-like L-NAME rat model : a focus on utero-placental dysfunction.
(2014)
Preeclampsia is a multi-system pregnancy syndrome characterized by the sudden onset of hypertension, escalated proteinuria and in some cases oedema usually after 20 weeks of gestation. Preeclampsia is further categorized ...
The spectrum of HIV related nephropathy in KwaZulu-Natal : a pathogenetic appraisal and impact of HAART.
(2012)
Sub-Saharan Africa bears 70% of the global HIV burden with KwaZulu-Natal (KZN) identified as
the epicenter of this pandemic. HIV related nephropathy (HIVRN) exceeds any other causes of
kidney diseases responsible for end ...
A quantification of heat load as assessed by indicators of tissue damage in rats.
(1984)
Heatstroke is an illness that occurs when body temperature is grossly
elevated, causing widespread tissue damage. The extent of tissue
damage depends on the level of body temperature elevation and the
duration. Despite ...
Host induced microevolution of ESX secretion systems of M. Tuberculosis.
(2013)
The ESX family of genes (esxA-W) in Mycobacterium tuberculosis (Mtb) encodes 23 effector
molecules influencing immunogenicity and pathogenicity. This study was aimed at
identifying and evaluating variations in ESX sequence ...
The role of natural killer cells in preventing HIV-1 acquisition and controlling disease progression.
(2013)
In sub-Saharan Africa, women carry a disproportionate burden of the Human
Immunodeficiency Virus Type 1 (HIV-1) pandemic. The high risk of HIV
acquisition in these women and the variability in their disease progression ...
Characterisation of Fumonisin B1 toxicity in a cancerous liver cell line- induction of tissue transglutaminase and the endoplasmic reticulum stress pathway.
(2013)
Fumonisin B1 (FB1) is a mycotoxin which is well characterised as a contaminant of maize and maize-based products worldwide, especially in South Africa. Its toxic effects have been associated with hepatotoxicity, nephrotoxicity ...