Pharmaceutical Sciences
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Cost-analysis of Misoprostol and Mifepristone versus Misoprostol and Methotrexate when used for medical termination of pregnancy in women of gestational age of 7 weeks and less at Embhuleni Hospital in Elukwatini, Mpumalanga.
(2019)Background: The purpose of the Republic of South Africa Choice on Termination of Pregnancy Act 92 of 1996 is to provide a safe and effective alternative to the rife illegal abortions taking place in South Africa. ... -
Knowledge, attitudes and practices of veterinarians on antibiotic use, resistance and its containment in South Africa.
(2021)The inappropriate use of antibiotics in the veterinary sector has led to antibiotic resistance (ABR), which negatively impacts animal health and welfare and indirectly on human health. Understanding the knowledge, ... -
Quantum plasmonic sensing with application to HIV research.
(2020)The main goal of this thesis is to show how the use of quantum states of light in biosensing with surface plasmon resonance (SPR) gives an enhancement over using classical states. SPR is a highly sensitive technique for ... -
Awareness, attitudes, and experiences of patients taking antiretrovirals towards adverse drug reactions at a public health facility in KwaZulu-Natal.
(2020)Adverse drug reactions (ADRs) are undesirable side effects that occur even when a drug is administered at the proper dose and correctly for an appropriate indication. Given the high prevalence of Human Immuno-deficiency ... -
Development of a tool to assess knowledge, awareness and perception of prostate cancer amongst women in Ghana.
(2020)Background and Objectives: The incidence of prostate cancer in developing countries is less than 30%, yet it has the disease's highest mortality. To address the mortality, strategies to increase awareness of the disease ... -
Retail pharmacy prescription medicines availability, prices, and affordability in Eswatini.
(2021)Background: The low availability of medicines in public health outlets coupled with unaffordable prices in the private sector can be a major barrier to medicines’ access. Patients in Eswatini may be forced to buy medicines ... -
Effects of Z-venusol and other pure compounds from medicinal plants on prostate, cervical and breast cancer cells.
(2017)Introduction According to recent World Health Organisation (WHO) estimates, cancer causes more deaths than coronary heart diseases globally (GLOBOCAN, 2012). While communicable diseases such as HIV/AIDS continue to ... -
Functional and molecular changes associated with intranasal buprenorphine in a healthy rodent model.
(2020)Opioid addiction is a spiralling global epidemic associated with intense drug craving and the compulsive use of opiate drugs such as heroin, oxycodone, oxymorphone amongst others. Buprenorphine (BUP), commercially available ... -
Molecular epidemiology of antibiotic-resistant Enterococcus spp. from farm-to-fork in intensive pig production in KwaZulu-Natal, South Africa.
(2021)Background: Substantial antibiotic use and high population densities in intensive farming systems results in the emergence and spread of antibiotic-resistant commensals and pathogens. This study investigated the molecular ... -
Molecular epidemiology of carbapenem-resistant Enterobacterales colonization in an intensive care unit.
(2021)Background: Due to the high association with mortality and morbidity, carbapenem-resistant Enterobacterales (CRE) in general, and carbapenem-resistant Klebsiella pneumoniae, in particular, have been listed as high-priority ... -
Mechanistic insights and in silico studies on selected G protein-coupled receptors implicated in HIV and neurological disorders.
(2021)G protein-coupled receptors (GPCRs) are the largest membrane protein receptor superfamily involved in a wide range of physiological processes. GPCRs form the major class of drug targets for a diverse array of pathophysiological ... -
Design and synthesis of novel pH-responsive fatty acid-based lipids for the development of nano-delivery systems to enhance Vancomycin activity against Methicillin-resistant Staphylococcus aureus (MRSA).
(2020)The ability of antimicrobials to prevent and treat infections caused by a range of microorganisms, including bacteria, is threatened by the emergence of drug-resistant microorganisms that is associated with high mortality ... -
The effects of naringenin on oxidative stress parameters in cardiac muscles of diabetic rats.
(2019)Introduction: Diabetic cardiomyopathy (DCM) is defined by hypertrophy, oxidative stress, fibrosis and inflammation of the cardiac muscle. Hyperglycemia-associated oxidative stress plays an important role in the development ... -
Synthesis and physiochemical characterization of new siderophore-inspired peptide-chelators with 1-hydroxypridine-2-one (1,2-HOPO).
(2020)Compounds containing hydroxamate moieties (N-hydroxyl amides) in their structure have found a vast range of therapeutic applications such as antibacterial, anti-tumour, anti-immune suppressor, and for iron overloading ... -
The role of kinins and cytokines in rheumatoid arthritis.
(2001)Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by inflammatory synovitis. The histopathological features include synovial hyperplasia, an inflammatory cell infiltration, angiogenesis ... -
An evaluation of knowledge, attitude and behaviour amongst patients regarding antibiotic use and misuse in South Africa.
(2020)Background: Antibiotic misuse is a global problem that presents a threat to public health. Antibiotic misuse and overuse are responsible for the increase and spread of antibiotic resistance. The community plays a fundamental ... -
Therapeutic strategy to end Tuberculosis (TB) world: structural and functional characterization of potential weak hotspots of Mycobacterium tuberculosis molecular targets from combinatorial in silico perspective.
(2021)The world has witnessed several decades of Tuberculosis (TB) pandemic and numerous advanced scientific efforts to control the invasiveness of the newly evolving Mycobacterium tuberculosis strains (Mtb) resulting in drug ... -
Computer-aided approaches in drug design: the exigent way forward: dynamic perspectives into the mechanistic activities of small molecule inhibitors toward antiviral, antitubercular and anticancer therapeutic interventions.
(2021)The crucial role of CADD in the drug design process is now indisputable and has proven over the years that it can accelerate the discovery potential drug candidates while reducing the associated cost. Using knowledge and ... -
Vasoactive peptides in acute renal allograft rejection and renal diseases: the role of endothelins, atrial natriuretic peptide and kinins.
(2001)Abstract available in PDF. -
In-silico investigation of CREB-binding protein on castration-resistant prostrate cancer: insight from molecular dynamic simulations and computer aided drug discovery.
(2020)Prostate cancer has evolved over the years despite various treatment and therapy. One recent threat of the prostate cancer is the Castration- Resistant Prostate Cancer (CRPC). The CRPC is an advanced form of prostate cancer. ...
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