Browsing Doctoral Degrees (Medical Biochemistry) by Issue Date
Now showing items 1-20 of 20
-
Molecular and biochemical aspects of the kallikrein-kinin system in oesophageal carcinoma.
(1999)Abstract available in PDF file. -
Biochemical, apoptotic and cellular stress studies in rheumatoid arthritis.
(2009)Abstract available in PDF file. -
An assessment of gene polymorphisms in young South African Indians with coronary artery disease and the effect of atorvastan in vitro.
(2012)The global burden of heart disease increases every year. It has been estimated that by the year 2020, coronary artery disease (CAD) will be the number one cause of death worldwide. Indian populations throughout the world ... -
Antibiotic resistance in the food chain : a case study of Campylobacter spp. in poultry.
(2013)The sub-therapeutic use of antibiotics for growth promotion in food animal production, has engendered substantial debate on the dissemination of antibiotic resistance via the food chain, specifically, the probability of ... -
An investigation into the biochemical, molecular and epigenetic effects of fumonisin B1 in liver (HEPG2) cells.
(2014)Fumonisins are carcinogenic mycotoxins that occur world wide in maize and maizebased products intended for human consumption. Consumption of fumonisincontaminated maize as a staple diet has been associated with oesophageal ... -
A biochemical assessment of stress response following acute and prolonged exposure to antiretroviral drugs (nucleoside reverse transcriptase inhibitors) in vitro.
(2015)Nucleoside reverse transcriptase inhibitors (NRTIs) are the most extensively used antiretroviral (ARV) drugs in highly active antiretroviral therapy (HAART). The long term use of HAART is associated with changes to metabolic ... -
An investigation into the TB/HIV manipulation of the T-cell immune response.
(2015)Abstract available in PDF file. -
An investigation into the clinical, biochemical, immunological and epigenetic factors in black South Africa women with preeclampsia and HIV.
(2015)Introduction: Preeclampsia (PE) and HIV/AIDS contribute significantly to adverse maternal and perinatal outcomes globally. The treatment of PE remains empiric, however in HIV infection, highly active antiretroviral therapy ... -
Hyperglycaemic-induced regulation of SIRT3 and downstream antioxidant profile.
(2015)Hyperglycaemia increases reactive oxygen species (ROS) production and mitochondrial dysfunction which are involved in metabolic disorders. Sirtuin 3 (SIRT3) is a primary mitochondrial deacetylase that regulates mitochondrial ... -
The antiproliferative and apoptosis inducing effects of Moringa oleifera aqueous leaf extract and its synthesised gold nanoparticles - modulation of oncogenes and tumour suppressor genes in human cancer cell lines.
(2015)Cancer is one of the leading causes of global mortality. In South Africa (SA), the burden of cancer (lung and oesophageal) continues to increase. Moringa oleifera (MO), indigenous to India, is found widely in SA and used ... -
Quantification of circulating cell free fetal DNA and cell free total DNA in normal pregnancy and in pregnancy-related hypertension in Black South African Women.
(2016)Abstract available in PDF file. -
Temporal gene expression of Chlamydia trachomatis in keratinocytes at 37° versus 33°C.
(2017)Abstract available in PDF file. -
An investigation of the anti-hyperglycaemic, biochemical and molecular effects of 4-hydroxyisoleucine and fenugreek seed extract in comparison to metformin in vitro and in vivo.
(2017)Type two diabetes mellitus (T2D) is a significant cause of premature death and disability, accompanied with negative socio-economic impacts. This metabolic disorder is characterized by hyperglycaemia and defective insulin ... -
An investigation of stress-responses in pregnant women exposed to ambient air pollution in Durban, South Africa.
(2017)Living or working within an unhealthy environment is attributed to 12.6 million deaths worldwide and 2.2 million deaths in Africa. Ambient air pollution (AAP) exposure is amongst the major contributors of environmental and ... -
A biochemical assessment of Ochratoxin A stress responses in vitro, with resveratrol as a possible therapeutic intervention.
(2017)Abstract available in PDF file. -
An in vitro and in vivo evaluation of the immuno and neurotoxicological effects of fusaric acid on altered protein kinase signalling cascades.
(2019)Mycotoxins are naturally occurring toxins produced by moulds which contaminate numerous crops and foodstuffs including cereals, nuts and fruits. When consumed, mycotoxins pose a serious threat to both human and animal ... -
An investigation into the molecular and Epigenetic alterations associated with Fumonisin B1-induced toxicity in human liver (HEPG2) cells.
(2020)The contamination of agricultural commodities with Fusarium mycotoxins is a global issue in food safety, with fumonisin B1 (FB1) being the most prevalent contaminant. FB1 is not only phytotoxic, but it induces a wide range ... -
The pathophysiology of cholesterol gallstones amongst Black South African women living with HIV.
(2021)Thirteen percent of South Africans are living with HIV and of those infected, 52% are on antiretroviral therapy (ART). ART has changed the course of this terminal illness to one of a chronic illness. However, the longer ... -
A pilot study: bisphenol A-glucuronide and their association with sex steroid hormones and 25 Hydroxy vitamin D among mother and child pairs.
(2021)Bisphenol A (BPA) is an endocrine disruptor that has become ubiquitous in our environment. It is utilised in numerous consumer products related to the manufacture of plastics. Exposure to BPA has been linked to a wide ...