Search

Now showing items 1-10 of 15

Association of TRIM22 with the Type 1 Interferon Response and Viral Control during Primary HIV-1 Infection.

Singh, Ravesh.; Gaiha, Gaurav.; Werner, Lise.; Mlisana, Koleka Patience.; Luban, Jeremy.; Walker, Bruce D.; Abdool Karim, Salim Safurdeen.; Ndung'u, Peter Thumbi.; Brass, Abraham.; McKim, Kevin. (American Society for Microbiology., 2010)

Type 1 interferons (IFNs) induce the expression of the tripartite interaction motif (TRIM) family of E3 ligases, but the contribution of these antiviral factors to HIV pathogenesis is not completely understood. We hypothesized ...

APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4R T-cell counts and plasma viral load.

Reddy, Kavidha.; Winkler, Cheryl Ann.; Werner, Lise.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Ndung'u, Peter Thumbi. (Lippincott Williams & Wilkins., 2008)

Objectives: In the absence of HIV-1 virion infectivity factor (Vif), cellular cytosine deaminases such as apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) inhibit the virus by inducing ...

Duffy-Null–Associated Low Neutrophil Counts Influence HIV-1 Susceptibility in High-Risk South African Black Women.

Ramsuran, Veron.; Kulkarni, Hemant.; He, Weijing.; Mlisana, Koleka Patience.; Wright, Edwina J.; Werner, Lise.; Castiblanco, John.; Dhanda, Rahul.; Le, Tuan.; Dolan, Matthew J.; Guan, Weihua.; Weiss, Robin A.; Clark, Robert A.; Abdool Karim, Salim Safurdeen.; Ahuja, Sunil K.; Ndung'u, Peter Thumbi. (Oxford University Press., 2010)

Background. The Duffy-null trait and ethnic netropenia are both highly prevalent in Africa. The influence of pre-seroconversion levels of peripheral blood cell counts (PBCs) on the risk of acquiring human immunodeficiency ...

Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population.

Mamtani, Manju.; Mummidi, Srinivas.; Ramsuran, Veron.; Pham, Minh-Hieu.; Maldonado, Robert.; Begum, Kazi.; Valera, Maria Soledad.; Sanchez, Racquel.; Castiblanco, John.; Kulkarni, Hemant.; Ndung'u, Peter Thumbi.; He, Weijing.; Anaya, Juan Manuel.; Ahuja, Sunil K. (Oxford University Press on behalf of The Infectious Diseases Society of America., 2010)

We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)–1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The ...

Conserved positive selection signals in HIV-1 gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection.

Martin, Darren Patrick.; Treurnicht, Florette K.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Gama, Bandawe P. (BioMed Central., 2008)

Background. The high diversity of HIV variants driving the global AIDS epidemic has caused many to doubt whether an effective vaccine against the virus is possible. However, by identifying the selective forces that are ...

Intersubtype differences in the effect of a rare p24 Gag mutation on HIV-1 replicative fitness.

Chopera, Denis Rutendo.; Cotton, Laura A.; Zawaira, Alexander.; Mann, Jaclyn Kelly.; Ngandu, Nobubelo K.; Ntale, Roman.; Carlson, Jonathan M.; Mlisana, Koleka Patience.; Woodman, Zenda.; de Assis Rosa, Debra.; Martin, Eric.; Miura, Toshiyuki.; Pereyra, Florencia.; Walker, Bruce D.; Gray, Clive M.; Martin, Darren Patrick.; Ndung'u, Peter Thumbi.; Brockman, Mark A.; Abdool Karim, Salim Safurdeen.; Brumme, Zabrina L.; Williamson, Carolyn. (American Society for Microbiology., 2012)

Certain immune-driven mutations in HIV-1, such as those arising in p24Gag, decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. ...

Transmission of HIV-1 CTL escape variants provides HLA - mismatched recipients with a survival advantage.

Chopera, Denis Rutendo.; Woodman, Zenda.; Mlisana, Koleka Patience.; Mlotshwa, Mandla.; Martin, Darren Patrick.; Seoighe, Cathal.; Treurnicht, Florette K.; de Assis Rosa, Debra.; Hide, Winston.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (Plos., 2007)

One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides ...

Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals.

Chopera, Denis Rutendo.; Mlotshwa, Mandla.; Woodman, Zenda.; Mlisana, Koleka Patience.; de Assis Rosa, Debra.; Martin, Darren Patrick.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (American Society for Microbiology., 2010)

Molecular epidemiology studies have identified HLA-B*58:01 as a protective HIV allele. However, not all B*58:01-expressing persons exhibit slow HIV disease progression. We followed six HLA-B*58:01-positive, HIV subtype ...

Temporal association of HLA-B81:01- and HLA-B39:10-mediated HIV-1 p24 sequence evolution with disease progression.

Ntale, Roman.; Chopera, Denis Rutendo.; Ngandu, Nobubelo K.; de Assis Rosa, Debra.; Zembe, Lycias.; Gamieldien, Hoyam.; Mlotshwa, Mandla.; Werner, Lise.; Woodman, Zenda.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (American Society for Microbiology., 2012)

HLA-B*81:01 and HLA-B*39:10 alleles have been associated with viremic control in HIV-1 subtype C infection. Both alleles restrict the TL9 epitope in p24 Gag, and cytotoxic-T-lymphocyte (CTL)-mediated escape mutations in ...

Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression.

Mlotshwa, Mandla.; Riou, Catherine.; Chopera, Denis Rutendo.; de Assis Rosa, Debra.; Ntale, Roman.; Treurnicht, Florette K.; Woodman, Zenda.; Werner, Lise.; van Loggerenberg, Francois.; Mlisana, Koleka Patience.; Williamson, Carolyn.; Gray, Clive M.; Abdool Karim, Salim Safurdeen. (American Society for Microbiology, 2010)

Deciphering immune events during early stages of human immunodeficiency virus type 1 (HIV-1) infection is critical for understanding the course of disease. We characterized the hierarchy of HIV-1-specific T-cell gamma ...