Doctoral Degrees (Biochemistry)
Recent Submissions
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The development and use of in vitro and in silico beta-site amyloid precursor protein cleaving enzyme-1 protein-ligand binding assays.
(2020)Abstract available in PDF. -
Anti-c-myc cholesterol-based lipoplexes: development, characterisation and evaluation as Onconanotherapeutic agents in vitro.
(2018)Strategies aimed at inhibiting the expression of the c-myc oncogene could provide the basis for alternative cancer treatment. In this regard, silencing c-myc expression using small interfering RNA (siRNA) is an attractive ... -
An investigation into the analytical, cytotoxicity and immunotoxicity of mycotoxins found in commercially available pelleted pet foods in Durban, South Africa.
(2018)Introduction: Dry pelleted dog food in the South African market is available via supermarket, pet stores (standard brands - SB) and veterinary channels (premium brands-PB). Similarly, cat food were viewed in two market ... -
Developing in vitro multi co-culture models and analysis tools for muscle regeneration.
(2019)Skeletal muscle regeneration represents a complex process mediated by non-myogenic cell types. These cells, such as macrophages and fibroblasts, display a range of interactions with muscle stem cells (myoblasts) during ... -
Evaluation of the anti-diabetic potentials of some African medicinal plants: a multimode study.
(2018)The present study investigated the effects of five African medicinal plants (Alstonia boonei, Acalypha wilkesiana, Boerhaavia diffusa, Bridelia ferruginea, and Crassocephalum rubens) for their antioxidative and antidiabetic ... -
Antidiabetic and toxicological properties of some African medicinal plants used in the treatment of diabetes and its complications.
(2018)This study investigated the antioxidant, antidiabetic and toxicity properties of antidiabetic medicinal plants comprising of Vernonia amygdalina, Cola nitida, Raffia palm (Raphia hookeri) wine, Phaseolus lunatus, Dacryodes ... -
Molecular characterisation of metacaspase 5 and the production of oligopeptidase b-specific single chain variable fragment antibodies for potential animal African trypanosomosis chemotherapies and diagnostics.
(2018)African trypanosomosis (AT) is a major obstacle in the establishment of agriculture and economic sustainability in Africa. Animal AT is responsible for large numbers of livestock succumbing to the tsetse transmitted ... -
Functionalised gold nanoparticle delivery for c-MYC siRNA in cancer gene therapy.
(2018)Abstract available in PDF file. -
Starburst poly-amidoamine dendrimer grafted gold nanoparticles as scaffolds for targeted gene delivery in vitro.
(2017)Abstract available in PDF file. -
Studies on the anti-hyperglycemic potentials and possible mode of actions of some commonly used sugar alcohols.
(2016)Abstract available in PDF file. -
Factors governing seed recalcitrance in two species of contrasting storage longevity.
(2017)Abstract available in PDF file. -
Mitochondrial localisation and cellular uptake in vitro using novel ‘mitochondriotropic’ liposomes.
(2016)Mitochondrial research has made tremendous strides since the 1980/90s when mitochondrial DNA mutations were first identified as a primary cause for human diseases and the organelle’s role in apoptosis was elucidated. These ... -
Expression of monocyte heat shock protein 70 (HSP70) during malaria fever in the presence of antimalarial, anti-inflammatory drugs and β-haematin.
(2017)Abstract available in PDF file. -
Antidiabetic properties of centella asiatica in type II diabetic rats.
(2016)Abstract available in PDF file. -
Synthesis, characterization and evaluation of antibacterial, antidiabetic and toxicological profiles of newly-derived therapeutic agents.
(2016)Abstract available in PDF file. -
Developing antibodies against Plasmodium lactate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase and phosphoethanolamine-N-methyltransferase
(2016)Abstract available in PDF file. -
Investigation of anti-diabetic properties of Psidium guajava leaf in streptozocin induced diabetic rats.
(2015)Diabetes mellitus results in chronic hyperglycaemia, leading to defects in carbohydrate, fat and protein metabolism. Diabetes mellitus is also linked with elevated plasma cholesterol and triglyceride levels, which may ... -
Antioxidative and antidiabetic effects of some African medicinal plants.
(2016)Three (3) medicinal plants [Aframomum melegueta K. Schum., Xylopia aethiopica (Dunal.) A. Rich. and Capsicum annuum L.] were selected based on their traditional uses in the treatment of diabetes in Africa. Various crude ...