Medical Microbiology
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Microbial profile and antimicrobial susceptibility patterns of neonatal blood stream infections in Durban, South Africa.
(2020)Objectives Antimicrobial resistance (AMR) has emerged as a global threat to healthcare resulting in an increase in morbidity and mortality. Neonatal sepsis is ranked as the third highest cause of neonatal demise globally, ... -
Molecular epidemiology of antibiotic resistant salmonella spp. from farm to fork in an intensive pig production system in KwaZulu-Natal South Africa.
(2021)Antibiotic resistance (ABR) is a worldwide challenge, and, if not resolved, can be a danger to humans, animals and the ecosystem. The inappropriate use and misuse of antibiotics in food animal production creates selection ... -
Defining the role of high-dose isoniazid in the treatment of multi-drug resistance tuberculosis: isoniazid resistant profiling.
(2021)Background: High-dose isoniazid is recommended in short-course regimens for multidrug-resistant tuberculosis (MDR-TB). However, there is no substantial evidence supporting its use in the presence of INH resistant mutations. ... -
Using neutrophil-specific biomarkers as a measure of Mycobacterium tuberculosis burden, lung damage and treatment response kinetics.
(2021)The spectrum of TB disease remains poorly characterized impacting case identification and linkage to care. Furthermore, the absence of simple, sensitive and easy to measure biomarkers of disease severity and treatment ... -
The role of Mycobacterium tuberculosis curli pili (MTP) and heparin-binding hemagglutinin adhesin (HBHA) on global in vitro bacterial transcriptomics.
(2021)Background/Aim: Tuberculosis (TB), is an infectious, airborne disease caused by Mycobacterium tuberculosis (M. tuberculosis). TB remains one of the most devastating bacterial causes of human mortality, especially in ... -
Fosfomycin: an oral treatment option for multi drug resistant uropathogens.
(2021)Introduction Urinary tract infections (UTIs) are commonplace in both the community and hospital environment where it is accepted clinical practice to treat empirically. Consequently, this has led to an alarming increase ... -
Molecular surveillance of Staphylococcus aureus on frequently touched sites in public hospitals in KwaZulu-Natal, South Africa.
(2021)There is an escalation in the prevalence of hospital-acquired infections (HAI) due to the transfer of pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), within the hospital environment. Pathogens ... -
Distribution, virulence and antimicrobial resistance profile of Bacillus species from the environment of four public hospitals in South Africa.
(2021)Hospital-acquired infections (HAIs) are counted as the most crucial global health crisis. The hospital environment may be colonized by opportunistic pathogens, which can lead to HAIs in hospitalized patients. As a result, ... -
The impact of semen exposure on the immune and microbial environments of the female genital tract.
(2021)Background: Semen is an immunomodulatory fluid that induces mucosal changes at the female genital tract (FGT) for sperm survival and conception. Semen-induced alterations necessary for reproduction may also modulate the ... -
Molecular epidemiology of antibiotic-resistant Escherichia coli and Enterococcus spp. from agricultural soil fertilized with chicken litter in uMgungundlovu district, KwaZulu-Natal Province, South Africa.
(2021)The application of animal manure contaminated with antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) represents a major route by which antibiotic resistance is transmitted into the soil environment. ... -
Hydrogen sulfide (H2S) production by mycobacteria.
(2020)The gasotransmitter hydrogen sulfide (H2S) has been recognized as a physiological mediator with a variety of functions across all domains of life. Many prokaryotic bacterial species endogenously generate H2S in their ... -
Characterization of immunoglobulin (Ig) isotypes, IgG subclasses and cytokines in the blood and genital tracts of HIV infected and healthy women from an observational cohort study (CAPRISA 082)
(2020)Background: Heterosexual transmission remains the dominant route of HIV infections in women. Immune responses that predict HIV acquisition during pre-exposure prophylaxis (PrEP) remain undefined. We hypothesized that ... -
Molecular epidemiology of antibiotic resistant Campylobacter spp. from farm-to-fork in an intensive pig production system in Kwazulu-Natal, South Africa.
(2021)Background: Campylobacter spp. are among the leading foodborne pathogens, causing Campylobacteriosis, a zoonotic infection that results in bacterial gastroenteritis and diarrhea disease in animals and humans. The emergence ... -
Molecular characterization of antibiotic-resistant Staphylococcus aureus in an intensive pig production system in KwaZulu-Natal, South Africa.
(2021)The increase in antibiotic resistance in food animals and food of animal origin has been attributed to the extensive use of antibiotics during animal husbandry giving rise to multidrug-resistant bacteria. Staphylococcus ... -
Enterococcus sp. contamination surveillance in different levels of healthcare in eThekwini District, KwaZulu-Natal (KZN) South Africa.
(2021)Hospital-acquired infections (HAIs) have been identified as long-standing setbacks affecting hospitals' quality of health care. While one of the major challenges related to HAIs is controlling cross-transmission, the ... -
Prevalence and molecular susceptibility of Mycoplasma genitalium in KwaZulu-Natal population.
(2021)Background: Mycoplasma genitalium is a recently classified sexually transmitted pathogen associated with causing urethritis and cervicitis, potentially causing reproductive complications. Mycoplasma genitalium has been ... -
Induction of secondary metabolite production in endophytic fungi isolated from Albizia adianthifolia using multiple small compounds involved in fungal chromatin remodeling.
(2021)Fungi are an inexhaustible source of unexplored bioactive secondary metabolites that have been useful to humans as pharmaceuticals and other valuable products. The unexplored arsenal of secondary metabolites from fungi ... -
Investigating the prevalence of vaginitis pathogens in HIV infected and uninfected pregnant women In Durban, South Africa.
(2020)BACKGROUND: Vaginitis in pregnancy significantly contributes to obstetric complications such as preterm labor. Human Immunodeficiency Virus (HIV) infection is thought to increase risk of acquiring vaginitis in pregnancy ... -
Global transcriptome analysis of THP-1 cells infected with an rpfB gene knockout strain of Mycobacterium tuberculosis.
(2021)Background: Since the initial isolation of Mycobacterium tuberculosis (Mtb), tuberculosis (TB) remains among the top 10 causes of death. In 2019, 10 million people globally were burdened with TB, of which 25 %were from ...
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