Browsing Masters Degrees (Medical Microbiology) by Title
Now showing items 1-20 of 66
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Antimicrobial properties of traditional medicine used for treatment of HIV/AIDS and its opportunistic infections.
(2012)This study was conducted to establish the scientific basis of the reported ethnomedicinal use of Ihlamvu laseAfrika (IHL) against Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Virus (AIDS) related ... -
Aspects of sexually transmitted diseases at King Edward VIII hospital.
(1988)Abstract available in PDF. -
Characterization of immunoglobulin (Ig) isotypes, IgG subclasses and cytokines in the blood and genital tracts of HIV infected and healthy women from an observational cohort study (CAPRISA 082)
(2020)Background: Heterosexual transmission remains the dominant route of HIV infections in women. Immune responses that predict HIV acquisition during pre-exposure prophylaxis (PrEP) remain undefined. We hypothesized that ... -
Cytokine production by ME-180 cells and VK2 E6/E7 cells on exposure to Neisseria gonorrhoeae, HIV, N. gonorrhoeae and HIV.
(2018)Gonorrhoea is a sexually transmitted disease caused by Neisseria gonorrhoeae. Women are more at risk in developing secondary complications due to asymptomatic infections. In 2001, a study was done on the different responses ... -
The cytotoxic effects of fumonisin B1 in human kidney cells and the ability of allicin to ameliorate these effects.
(2019)Fumonisin B1 (FB1) is a widespread contaminant of crops and is produced as a secondary metabolite of fungi. It has been found to disrupt sphingolipid metabolism, cause epigenetic modifications and induce cellular toxicity ... -
Defining the role of high-dose isoniazid in the treatment of multi-drug resistance tuberculosis: isoniazid resistant profiling.
(2021)Background: High-dose isoniazid is recommended in short-course regimens for multidrug-resistant tuberculosis (MDR-TB). However, there is no substantial evidence supporting its use in the presence of INH resistant mutations. ... -
A descriptive analysis of the routine use of genotype MTBDRsl in a high HIV/TB prevalent region in South Africa.
(2020)Background. Since the implementation of shortened drug regimens for the management of drug resistant tuberculosis (TB), there is a growing need for rapid detection of resistance to second line antimycobacterial drugs. The ... -
The development and application of a high throughput methodology to determine MICs of Mycobacterium tuberculosis isolates against antimicrobial agents.
(2014)Chapter 1 of this dissertation entails the introduction, aims, objectives and the literature review. Drug susceptibility testing of Mycobacterium tuberculosis is time consuming and expensive. Multi-point inoculation offers ... -
The development of a stratified keratinocyte model for chlamydia trachomatis pathogenesis studies.
(2017)A number of different methods to generate stratified keratinocyte layers have been published. These involved the use of normal human epidermal keratinocytes (NHEKs/NEKS), which have a better ability to stratify compared ... -
Development of an antigen detection based point-of-care test for the diagnosis of primary syphilis.
(2011)Aim: To develop an antigen detection based, point-of-care test that will rapidly exclude syphilitic infection in patients presenting with genital ulcers. Materials and Method: T. pallidum subsp pallidum, Nichols strain, ... -
Differences in the susceptibility of mycobacterium tuberculosis to the 1st and 2nd line antituberculosis drugs under aerobic and anaerobic conditions.
(2015)Although Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is now considered a facultative anaerobe, and bacilli isolated from sputum specimen possess morphologies identified from bacilli growing ... -
Distribution, virulence and antimicrobial resistance profile of Bacillus species from the environment of four public hospitals in South Africa.
(2021)Hospital-acquired infections (HAIs) are counted as the most crucial global health crisis. The hospital environment may be colonized by opportunistic pathogens, which can lead to HAIs in hospitalized patients. As a result, ... -
Drug susceptibility testing of second and third line anti-tuberculosis drugs used in the management of extensively drug resistant tuberculosis.
(2013)Drug resistant tuberculosis is a major contributor to South Africa’s quadruple burden of disease. Management of this infection in a highly HIV endemic area is a constant challenge. There is a paucity of new anti-tuberculosis ... -
The effect of antimicrobials used for genital discharge disease on trichomonas vaginalis.
(2017)Trichomoniasis is the most common sexually transmitted infection caused by the protozoan, Trichomonas vaginalis. T. vaginalis infection is often asymptomatic. This infection causes vaginal discharge in women and urethritis ... -
The effect of genital tract inflammation on HIV-specific binding antibodies, IgG subclass and Isotype transudation.
(2019)Abstract available in PDF file. -
Evaluation of the MTT and MABA assays for rapid screening of the in vitro activity of synthetic chalcones against Mycobacterium tuberculosis.
(2014)Background: The chalcone scaffold (1,3-diaryl-2-propen-i-ones) has the advantage of easy chemical modification and has been shown to possess biological activity against a variety of organisms, including a wide range of ... -
Fosfomycin: an oral treatment option for multi drug resistant uropathogens.
(2021)Introduction Urinary tract infections (UTIs) are commonplace in both the community and hospital environment where it is accepted clinical practice to treat empirically. Consequently, this has led to an alarming increase ... -
Fumonisin B1 increases the NAD-dependant deacetylase SIRT1 to disrupt cholesterol flux in galactose supplemented HepG2 cells.
(2020)The Fusarium species are major fungal contaminants of maize, that produce an extremely toxic mycotoxin called Fumonisin B1 (FB1). Fumonisin B1 is a known causative agent of animal-related mycotoxicosis and is implicated ...