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CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.

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dc.contributor.authorValley-Omar, Ziyaad.
dc.contributor.authorSibeko, Sengeziwe.
dc.contributor.authorAnderson, Jeffrey A.
dc.contributor.authorGoodier, Sarah A.
dc.contributor.authorWerner, Lise.
dc.contributor.authorArney, Leslie.
dc.contributor.authorNaranbhai, Vivek.
dc.contributor.authorTreurnicht, Florette K.
dc.contributor.authorAbrahams, Melissa-Rose.
dc.contributor.authorBandawe, Gama P.
dc.contributor.authorSwanstrom, Ronald.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorAbdool Karim, Quarraisha.
dc.contributor.authorWilliamson, Carolyn.
dc.date.accessioned2012-11-23T07:39:15Z
dc.date.available2012-11-23T07:39:15Z
dc.date.created2011
dc.date.issued2011
dc.description.abstractAlterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus–infected source host to the newly infected individual. We used heteroduplex tracking assay and single-genome sequencing to investigate the effect of a tenofovir-based microbicide gel on the transmission bottleneck in women who seroconverted during the CAPRISA 004 microbicide trial. Seventy-seven percent (17 of 22; 95% confidence interval [CI], 56%–90%) of women in the tenofovir gel arm were infected with a single virus compared with 92% (13 of 14; 95% CI, 67%–>99%) in the placebo arm (P = .37). Tenofovir gel had no discernable impact on the transmission bottleneck.en
dc.identifier.citationValley-Omar, Z. et al. 2012. CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck. J Infect Dis. 206 (1) pp. 35-40.en
dc.identifier.issn0022-1899
dc.identifier.urihttp://dx.doi.org/ 10.1093/infdis/jis305en
dc.identifier.urihttp://hdl.handle.net/10413/7959
dc.language.isoenen
dc.publisherOxford University Press.en
dc.subjectHIV infections--Treatment.en
dc.subject.otherTenofovir.en
dc.subject.otherTenofovir microbicide trials.en
dc.titleCAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.en
dc.typePeer reviewed journal articleen

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