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Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.

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dc.contributor.authorArchary, Derseree.
dc.contributor.authorRong, Rong.
dc.contributor.authorGordon, Michelle Lucille.
dc.contributor.authorBoliar, Saikat.
dc.contributor.authorMadiga, Maphuti C.
dc.contributor.authorGray, Elin Solomonovna.
dc.contributor.authorDugast, Anne-Sophie.
dc.contributor.authorHermanus, Tandile.
dc.contributor.authorGoulder, Philip Jeremy Renshaw.
dc.contributor.authorCoovadia, Hoosen Mahomed.
dc.contributor.authorWerner, Lise.
dc.contributor.authorMorris, Lynn.
dc.contributor.authorAlter, Galit.
dc.contributor.authorDerdeyn, Cynthia A.
dc.contributor.authorNdung'u, Peter Thumbi.
dc.date.accessioned2013-07-02T11:10:03Z
dc.date.available2013-07-02T11:10:03Z
dc.date.created2012
dc.date.issued2012
dc.description.abstractNeutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically infected individuals with heterogeneous rates of disease progression. Autologous nAb titers of study exit plasma against study entry viruses were significantly higher than contemporaneous responses at study entry (p=0.002) and exit (p=0.01). NAb breadth and potencies against subtype C viruses were significantly higher than for subtype A (p=0.03 and p=0.01) or B viruses (p=0.03; p=0.05) respectively. Gp41-IgG binding affinity was higher than gp120-IgG (p=0.0002). IgG–FcγR1 affinity was significantly higher than FcγRIIIa (p<0.005) at study entry and FcγRIIb (p<0.05) or FcγRIIIa (p<0.005) at study exit. Evolving IgG binding suggests alteration of immune function mediated by binding antibodies. Evolution of nAbs was a potential marker of HIV-1 disease progression.en
dc.identifier.citationArchary, D. et al. 2012. Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. Virology 433 (2) pp. 410-420.en
dc.identifier.issn0042-6822
dc.identifier.urihttp://dx.doi.org/10.1016/j.virol.2012.08.033en
dc.identifier.urihttp://hdl.handle.net/10413/9243
dc.language.isoenen
dc.publisherElsevier.en
dc.subjectHIV infections--Virology.en
dc.subjectAIDS vaccines.en
dc.subject.otherNeutralizing antibodies.en
dc.subject.otherBinding antibodies.en
dc.subject.otherHIV-1 subtype C.en
dc.titleCharacterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection.en
dc.typePeer reviewed journal articleen

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