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Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression.

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dc.contributor.authorRoberts, Lindi.
dc.contributor.authorWilliamson, Carolyn.
dc.contributor.authorLittle, Francesca.
dc.contributor.authorBebell, Lisa M.
dc.contributor.authorMlisana, Koleka Patience.
dc.contributor.authorBurgers, Wendy A.
dc.contributor.authorPassmore, Jo-Ann Shelley.
dc.contributor.authorvan Loggerenberg, Francois.
dc.contributor.authorWalzl, Gerhard.
dc.contributor.authorDjoba Siawaya, Joel Fleury.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorAbdool Karim, Quarraisha.
dc.date.accessioned2012-11-28T12:58:20Z
dc.date.available2012-11-28T12:58:20Z
dc.date.created2010
dc.date.issued2010
dc.description.abstractBackground: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression. Although the acute phase of HIV infection is associated with increased pro-inflammatory cytokine production, the relationship between cytokine concentrations and HIV pathogenesis is unknown. Objectives: To identify cytokine biomarkers measurable in plasma during acute HIV-1 infection that predict HIV disease progression. Design: Study including 40 South African women who became infected with HIV-1 and were followed longitudinally from the time of infection. Methods: The concentrations of 30 cytokines in plasma from women with acute HIV-1 infection were measured and associations between cytokine levels and both viral load set point 12 months postinfection and time taken for CD4 cell counts to fall below 350 cells/ul were determined using multivariate and Cox proportional hazards regression. Results: We found that the concentrations of five plasma cytokines, IL-12p40, IL-12p70, IFN-y, IL-7 and IL-15 in women with acute infection predicted 66% of the variation in viral load set point 12 months postinfection. IL-12p40, IL-12p70 and IFN-y were significantly associated with lower viral load, whereas IL-7 and IL-15 were associated with higher viral load. Plasma concentrations of IL-12p40 and granulocyte–macrophage colony-stimulating factor during acute infection were associated with maintenance of CD4 cell counts above 350 cells/ul, whereas IL-1a, eotaxin and IL-7 were associated with more rapid CD4 loss. Conclusion: A small panel of plasma cytokines during acute HIV-1 infection was predictive of long-term HIV disease prognosis in this group of South African women.en
dc.identifier.citationRoberts, L. et al. 2010. Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. Aids. 24(6), pp. 819–831.en
dc.identifier.issn0269-9370
dc.identifier.urihttp://dx.doi.org/10.1097/QAD.0b013e3283367836en
dc.identifier.urihttp://hdl.handle.net/10413/8033
dc.language.isoenen
dc.publisherLippincott Williams & Wilkins.en
dc.subjectHIV (Viruses)en
dc.subjectHIV infections.en
dc.subject.otherCytokines.en
dc.subject.otherViral load.en
dc.titlePlasma cytokine levels during acute HIV-1 infection predict HIV disease progression.en
dc.typePeer reviewed journal articleen

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