Repository logo
 

Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection.

Simple item page
dc.contributor.authorO'Donnell, Max Roe.
dc.contributor.authorPadayatchi, Nesri.
dc.contributor.authorKvasnovsky, Charlotte.
dc.contributor.authorWerner, Lise.
dc.contributor.authorMaster, Iqbal.
dc.contributor.authorHorsburgh, Charles Robert.
dc.date.accessioned2013-07-01T13:12:30Z
dc.date.available2013-07-01T13:12:30Z
dc.date.created2013
dc.date.issued2013
dc.description.abstractHigh mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. We report treatment outcomes for adult XDR TB patients in KwaZulu-Natal Province, South Africa. Initial data were obtained retrospectively, and outcomes were obtained prospectively during 24 months of treatment. A total of 114 XDR TB patients were treated (median 6 drugs, range 3–9 drugs); 82 (73%) were HIV positive and 50 (61%) were receiving antiretroviral therapy. After receiving treatment for 24 months, 48 (42%) of 114 patients died, 25 (22%) were cured or successfully completed treatment, 19 (17%) defaulted from the study, and 22 (19%) showed treatment failure. A higher number of deaths occurred among HIV-positive patients not receiving antiretroviral therapy and among patients who did not show sputum culture conversion. Culture conversion was a major predictor of survival but was poorly predictive (51%) of successful treatment outcome.en
dc.identifier.citationO’Donnell, M.R., et al. 2013. Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection. Emerg Infect Dis. 19 (3) pp. 416-424.en
dc.identifier.issn1080-6040
dc.identifier.urihttp://dx.doi.org/10.3201/eid1903.120998en
dc.identifier.urihttp://hdl.handle.net/10413/9236
dc.language.isoenen
dc.publisherU.S. National Center for Infectious Diseases.en
dc.subjectMultidrug-resistant tuberculosis--KwaZulu-Natal.en
dc.subjectMultidrug-resistant tuberculosis--Treatment.en
dc.subjectHIV infections--Treatment--KwaZulu-Natal.en
dc.subjectHIV infections--Complications--KwaZulu-Natal.en
dc.subject.otherExtensively drug-resistant tuberculosis.en
dc.subject.otherXDR-TB.en
dc.subject.otherCoinfection.en
dc.titleTreatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection.en
dc.typePeer reviewed journal articleen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
O'Donnell_Max_R_2013.pdf
Size:
462.15 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.64 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research papers (Caprisa)