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Adolescents and HIV clinical trials: ethics, culture, and context.

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dc.contributor.authorMacQueen, Kathleen M.
dc.contributor.authorAbdool Karim, Quarraisha.
dc.date.accessioned2013-05-22T06:58:16Z
dc.date.available2013-05-22T06:58:16Z
dc.date.created2007
dc.date.issued2007
dc.description.abstractOne quarter of HIV infections globally occur among young people 15-24 years of age and more than half of all new infections are to people younger than 25 years. Clearly, there is a need to identify and implement effective HIV prevention strategies among at-risk teens. Some of the most effective options for slowing the epidemic are biomedical and several promising methods are in development, including microbicides, vaccines, and pre-exposure prophylaxis (PREP) or the daily use of antiretrovirals to prevent the acquisition of HIV. There is widespread reluctance to enroll minors in such biomedical prevention trials due to concerns about vulnerability related to physical maturity, experiential maturity, and diminished autonomy as well as legal and social challenges that vary across and within nations. However, excluding minors from trials misses an important opportunity to evaluate the effectiveness, acceptability, and safety of innovative interventions under the best conditions for identifying and resolving potential problems. The challenges of including minors in HIV prevention trials are highlighted via the example of one rural South African community that has been particularly devastated by the HIV epidemic.en
dc.description.notesThe publisher's final edited version of this article is available at : http://dx.doi.org/ 10.1016/j.jana.2007.01.002en
dc.identifier.citationMacQueen, K.M., Abdool Karim, Q. 2007. Adolescents and HIV clinical trials: ethics, culture, and context. Journal of the Association of Nurses in AIDS Care. 18 (2) pp. 78-82.en
dc.identifier.issn1055-3290
dc.identifier.urihttp://dx.doi.org/10.1016/j.jana.2007.01.002en
dc.identifier.urihttp://hdl.handle.net/10413/8950
dc.language.isoenen
dc.publisherElsevier.en
dc.subjectHIV infections--Prevention.en
dc.subjectAIDS (Disease) in adolescence--Prevention.en
dc.subjectAIDS (Disease) in adolescence.en
dc.subjectClinical trials--Moral and ethical aspects.en
dc.subjectAIDS (Disease)--Research.en
dc.subject.otherHIV prevention trials.en
dc.titleAdolescents and HIV clinical trials: ethics, culture, and context.en
dc.typePeer reviewed journal articleen

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