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Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection.

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dc.contributor.authorMoore, Penelope L.
dc.contributor.authorDecker, Julie M.
dc.contributor.authorBibollet-Ruche, F.
dc.contributor.authorLi, Hui.
dc.contributor.authorLeseka, N.
dc.contributor.authorGray, Elin Solomonovna.
dc.contributor.authorChoge, Isaac Ang'Ang'A.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorTreurnicht, Florette K.
dc.contributor.authorMlisana, Koleka Patience.
dc.contributor.authorShaw, George M.
dc.contributor.authorWilliamson, Carolyn.
dc.contributor.authorMorris, Lynn.
dc.date.accessioned2012-12-13T13:33:36Z
dc.date.available2012-12-13T13:33:36Z
dc.date.created2007-03-22
dc.date.issued2007-03-22
dc.description.abstractThe study of the evolution and specificities of neutralizing antibodies during the course of human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of possible targets for vaccine design. In this study, we assessed the autologous and heterologous neutralization responses of 14 HIV-1 subtype C-infected individuals, using envelope clones obtained within the first 2 months postinfection. Our data show that potent but relatively strain-specific neutralizing antibodies develop within 3 to 12 months of HIV-1 infection. The magnitude of this response was associated with shorter V1-to-V5 envelope lengths and fewer glycosylation sites, particularly in the V1-V2 region. Anti-MPER antibodies were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing antibodies. However, neither anti-MPER nor anti-CD4i antibody specificity conferred neutralization breadth. These data provide insights into the kinetics, potency, breadth, and epitope specificity of neutralizing antibody responses in acute HIV-1 subtype C infection.en
dc.identifier.citationGray, E.S. et al. 2007. Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. Journal of Virology 81 (12), pp. 6187-6196.en
dc.identifier.issn0022-538X
dc.identifier.urihttp://dx.doi.org/10.1128/jvi.00239-09en
dc.identifier.urihttp://hdl.handle.net/10413/8239
dc.language.isoenen
dc.publisherAmerican society for Microbiology.en
dc.subjectAntibody formation--Immunology.en
dc.subjectAntibodies--Analysis.en
dc.subjectAIDS vaccines--Research.en
dc.subjectAIDS-related opportunistic infections.en
dc.subject.otherAIDS.en
dc.subject.otherHIV.en
dc.subject.otherAcute human immunodeficiency.en
dc.titleNeutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection.en
dc.typePeer reviewed journal articleen

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