Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point.
| dc.contributor.author | Riou, Catherine. | |
| dc.contributor.author | Burgers, Wendy A. | |
| dc.contributor.author | Mlisana, Koleka Patience. | |
| dc.contributor.author | Roederer, Mario. | |
| dc.contributor.author | Abdool Karim, Salim Safurdeen. | |
| dc.contributor.author | Williamson, Carolyn. | |
| dc.contributor.author | Gray, Clive M. | |
| dc.contributor.author | Koup, Richard A. | |
| dc.date.accessioned | 2016-11-01T08:49:45Z | |
| dc.date.available | 2016-11-01T08:49:45Z | |
| dc.date.created | 2014 | |
| dc.date.issued | 2014 | |
| dc.description | CAPRISA, 2014. | en_US |
| dc.description.abstract | Defining the characteristics of HIV-specific CD8(+) T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8(+) response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point. | en_US |
| dc.identifier.citation | Riou, C., Burgers, W.A., Mlisana, K., Koup, R.A., Roederer, M., Karim, S.S.A., Williamson, C. and Gray, C.M. 2014. Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point. Journal of virology 88(3), 1819-1824. | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1128/JVI.02968-13 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10413/13554 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Society for Microbiology. | en_US |
| dc.subject | HIV Infections/immunology. | en_US |
| dc.subject | HIV-1/genetics. | en_US |
| dc.subject | Cohort Studies. | en_US |
| dc.title | Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point. | en_US |
| dc.type | Peer reviewed journal article | en_US |