The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa.
| dc.contributor.author | Ramjee, Gita. | |
| dc.contributor.author | Williams, Brian G. | |
| dc.contributor.author | Gouws, Eleanor. | |
| dc.contributor.author | Van Dyck, Eddy. | |
| dc.contributor.author | De Deken, Benedicte. | |
| dc.contributor.author | Abdool Karim, Salim Safurdeen. | |
| dc.date.accessioned | 2013-05-21T08:39:04Z | |
| dc.date.available | 2013-05-21T08:39:04Z | |
| dc.date.created | 2004 | |
| dc.date.issued | 2004 | |
| dc.description.abstract | This study investigated the impact of prevalent and incident HSV-2 infection on the incidence of HIV-1 infection in a cohort of female commercial sex workers in KwaZulu-Natal, South Africa. Prior to a vaginal microbicide trial, 416 women were screened for antibodies to HIV-1 and herpes simplex virus-2 (HSV-2) infections and a questionnaire was used to establish behavioral, social, and demographic characteristics. A total of 187 HIV-1-seronegative women were followed up at monthly intervals when blood was drawn and used to detect HIV-1 and HSV-2 antibodies. The median duration of follow-up was 2.2 years. At screening 50% of the women were HIV-1 seropositive and 84% were HSV-2 seropositive. The hazards of HIV-1 among women who were HSV-2 seropositive or seronegative throughout, or among those who seroconverted during the study, were not significantly different. When HSV-2 seroconversion was analyzed as a time-dependent covariate, the hazard ratio for HIV-1 seroconversion was 6.0 (95% CI: 2.6–14.0) times greater among women with incident than among women with prevalent HSV-2 infections. Drawing on other recent studies these data suggest that incident HSV-2 infection increases the risk of HIV-1 infection; the effect wanes with time since infection; and the effect is significantly greater for men than it is for women. | en |
| dc.identifier.citation | Ramjee, G., et al. 2005. The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa. J Acquir Immune Defic Syndr 39(3) pp. 333–339. | en |
| dc.identifier.issn | 1525-4135 | |
| dc.identifier.uri | http://hdl.handle.net/10413/8946 | |
| dc.language.iso | en | en |
| dc.publisher | Lippincott Williams & Wilkins. | en |
| dc.subject | AIDS (Disease)--Epidemiology. | en |
| dc.subject | HIV infections--Epidemiology. | en |
| dc.subject | Herpes simplex virus. | en |
| dc.subject | Prostitutes--Diseases--South Africa. | en |
| dc.subject.other | Sex workers. | en |
| dc.title | The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa. | en |
| dc.type | Peer reviewed journal article | en |