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A systematic review of definitions of extreme phenotypes of HIV control and progression.

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dc.contributor.authorGurdasani, Deepti.
dc.contributor.authorIles, Louise.
dc.contributor.authorDillon, David G.
dc.contributor.authorYoung, Elizabeth H.
dc.contributor.authorOlson, Ashley D.
dc.contributor.authorNaranbhai, Vivek.
dc.contributor.authorFidler, Sarah.
dc.contributor.authorGkrania-Klotsas, Effrossyni.
dc.contributor.authorPost, Frank A.
dc.contributor.authorKellam, Paul.
dc.contributor.authorPorter, Kholoud.
dc.contributor.authorSandhu, Manjinder S.
dc.date.accessioned2016-10-25T08:44:04Z
dc.date.available2016-10-25T08:44:04Z
dc.date.created2014
dc.date.issued2014
dc.descriptionCAPRISA, 2014.en_US
dc.description.abstractThe study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlying these phenotypes. In this systematic review, we formally quantified the heterogeneity in definitions used for terms referring to extreme phenotypes in the literature, and identified common definitions and components used to describe these phenotypes. We assessed 714 definitions of HIV extreme phenotypes in 501 eligible studies published between 1 January 2000 and 15 March 2012, and identified substantial variation among these. This heterogeneity in definitions may represent important differences in biological endophenotypes and clinical progression profiles of individuals selected by these, suggesting the need for harmonized definitions. In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection.en_US
dc.identifier.citationGurdasani, D., Iles, L., Dillon, D.G., Young, E.H., Olson, A.D., Naranbhai, V., Fidler, S., Gkrania-Klotsas, E., Post, F.A., Kellam, P. and Porter, K. 2014. A systematic review of definitions of extreme phenotypes of HIV control and progression. AIDS 28(2), 149-162.en_US
dc.identifier.urihttp://dx.doi.org/10.1097/QAD.0000000000000049en_US
dc.identifier.urihttp://hdl.handle.net/10413/13542
dc.language.isoenen_US
dc.publisherWolters Kluwer Health.en_US
dc.subjectDefinitions.en_US
dc.subjectElite controllers.en_US
dc.subjectExtreme-trait designs.en_US
dc.subjectHIV.en_US
dc.subjectHIV controllers.en_US
dc.subjectLong-term nonprogressors.en_US
dc.subjectPhenotypes.en_US
dc.subjectSlow progressors.en_US
dc.subjectSystematic review.en_US
dc.subjectViremic controllers.en_US
dc.titleA systematic review of definitions of extreme phenotypes of HIV control and progression.en_US
dc.typePeer reviewed journal articleen_US

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