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Transmission of HIV-1 CTL escape variants provides HLA - mismatched recipients with a survival advantage.

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dc.contributor.authorChopera, Denis Rutendo.
dc.contributor.authorWoodman, Zenda.
dc.contributor.authorMlisana, Koleka Patience.
dc.contributor.authorMlotshwa, Mandla.
dc.contributor.authorMartin, Darren Patrick.
dc.contributor.authorSeoighe, Cathal.
dc.contributor.authorTreurnicht, Florette K.
dc.contributor.authorde Assis Rosa, Debra.
dc.contributor.authorHide, Winston.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorGray, Clive M.
dc.contributor.authorWilliamson, Carolyn.
dc.date.accessioned2013-04-08T06:21:17Z
dc.date.available2013-04-08T06:21:17Z
dc.date.created2007
dc.date.issued2007
dc.description.abstractOne of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B*57 or B*5801 alleles, for example, target functionally important parts of the Gag protein. Mutants that escape these CTL responses may have lower fitness than the wild-type and can be associated with slower disease progression. Transmission of the escape variant to individuals without these HLA alleles is associated with rapid reversion to wild-type. However, the question of whether infection with an escape mutant offers an advantage to newly infected hosts has not been addressed. Here we investigate the relationship between the genotypes of transmitted viruses and prognostic markers of disease progression and show that infection with HLA-B*57/B*5801 escape mutants is associated with lower viral load and higher CD4+ counts.en
dc.identifier.citationChopera, D., et al. 2008. Transmission of HIV-1 CTL escape variants provides HLA - mismatched recipients with a survival advantage. Plos Pathogens 4(3): e1000033. doi:10.1371/journal.ppat.1000033en
dc.identifier.issn1553-7366
dc.identifier.urihttp://dx.doi.org/1000033. doi:10.1371/journal.ppat.1000033en
dc.identifier.urihttp://hdl.handle.net/10413/8769
dc.language.isoenen
dc.publisherPlos.en
dc.subjectHIV infections--Genetic aspects.en
dc.subjectHIV infections--Virology.en
dc.subjectHIV infections--Transmission.en
dc.titleTransmission of HIV-1 CTL escape variants provides HLA - mismatched recipients with a survival advantage.en
dc.typePeer reviewed journal articleen

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