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Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial.

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dc.contributor.authorDezzutti, Charlene S.
dc.contributor.authorRichardson, Barbra Ann.
dc.contributor.authorMarrazzo, Jeanne M.
dc.contributor.authorTugetman, Jessica.
dc.contributor.authorRamjee, Gita.
dc.contributor.authorTaha, Taha E.
dc.contributor.authorChirenje, Zvavahera Mike.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorHillier, Sharon Louise.
dc.contributor.authorHerold, Betsy C.
dc.date.accessioned2013-07-01T13:18:25Z
dc.date.available2013-07-01T13:18:25Z
dc.date.created2012
dc.date.issued2012
dc.description.abstractThe mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HβD-2 (odds ratio [OR], 2.39; P = .005) and greater Escherichia coli bactericidal activity (OR, 1.22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition.en
dc.identifier.citationDezzutti, C.S. et al. 2012. Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial. J Infect Dis. 206 (12) pp. 1931-1935.en
dc.identifier.issn0022-1899
dc.identifier.urihttp://dx.doi.org/10.1093/infdis/jis555en
dc.identifier.urihttp://hdl.handle.net/10413/9241
dc.language.isoenen
dc.publisherOxford University Press on behalf of the Infectious Diseases Society of America.en
dc.subjectAIDS (Disease) in women.en
dc.subject.otherHPTN 035 trial.en
dc.subject.otherPre-exposure prophylaxis (PrEP)en
dc.titleMucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial.en
dc.typePeer reviewed journal articleen

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