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High treatment failure and default rates for patients with multidrug-resistant tuberculosis in KwaZulu-Natal, South Africa, 2000–2003.

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dc.contributor.authorBrust, James C. M.
dc.contributor.authorGandhi, Neel R.
dc.contributor.authorCarrara, H.
dc.contributor.authorOsburn, G.
dc.contributor.authorPadayatchi, Nesri.
dc.date.accessioned2012-11-28T13:01:04Z
dc.date.available2012-11-28T13:01:04Z
dc.date.created2009
dc.date.issued2009
dc.description.abstractSETTING: Multidrug-resistant tuberculosis (MDR-TB) has emerged as a significant public health threat in South Africa. OBJECTIVE: To describe treatment outcomes and determine risk factors associated with unfavorable outcomes among MDR-TB patients admitted to the provincial TB referral hospital in KwaZulu-Natal Province, South Africa. DESIGN: Retrospective observational study of MDR-TB patients admitted from 2000 to 2003. RESULTS: Of 1209 MDR-TB patients with documented treatment outcomes, 491 (41%) were cured, 35 (3%) completed treatment, 208 (17%) failed treatment, 223 (18%) died and 252 (21%) defaulted. Of the total number of patients with known human immunodeficiency virus (HIV) status, 52% were HIV-infected. Treatment failure, death and default each differed in their risk factors. Greater baseline resistance (aOR 2.3-3.0), prior TB (aOR 1.7), and diagnosis in 2001, 2002 or 2003 (aOR 1.9-2.3) were independent risk factors for treatment failure. HIV co-infection was a risk factor for death (aOR 5.6), and both HIV (aOR 2.0) and male sex (aOR 1.9) were risk factors for treatment default. CONCLUSION: MDR-TB treatment outcomes in KwaZulu-Natal were substantially worse than those published from other MDR-TB cohorts. Interventions such as concurrent antiretroviral therapy and decentralized MDR-TB treatment should be considered to improve MDR-TB outcomes in this high HIV prevalence setting.en
dc.identifier.citationBrust, J.C.M. et al. 2010. High treatment failure and default rates for patients with multidrug-resistant tuberculosis in KwaZulu-Natal, South Africa, 2000-2003. Int J Tuberc Lung Dis 14(4), pp. 413–419.en
dc.identifier.issn1027-3719
dc.identifier.urihttp://hdl.handle.net/10413/8034
dc.language.isoenen
dc.publisherThe Union.en
dc.subjectMultidrug-resistant tuberculosis--Treatment.en
dc.subjectMultidrug-resistant tuberculosis--KwaZulu-Natal.en
dc.subjectDrug resistance.en
dc.subjectHIV infections--Complications.en
dc.titleHigh treatment failure and default rates for patients with multidrug-resistant tuberculosis in KwaZulu-Natal, South Africa, 2000–2003.en
dc.typePeer reviewed journal articleen

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