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Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel.

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dc.contributor.authorNaranbhai, Vivek.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorAltfeld, Marcus.
dc.contributor.authorSamsunder, Natasha.
dc.contributor.authorDurgiah, Raveshni.
dc.contributor.authorSibeko, Sengeziwe.
dc.contributor.authorAbdool Karim, Quarraisha.
dc.contributor.authorCarr, William Henry.
dc.date.accessioned2013-06-25T07:30:35Z
dc.date.available2013-06-25T07:30:35Z
dc.date.created2011
dc.date.issued2011
dc.description.abstractThe antiretroviral agent, tenofovir, formulated as a vaginal microbicide gel, reduces human immunodeficiency virus (HIV) acquisition by 39% in women. This study assessed the role of preexisting immune activation in HIV acquisition in women from the CAPRISA 004 trial, to identify potential strategies to increase the effectiveness of tenofovir gel. Systemic cytokine and cellular immune mediators (platelets and natural killer [NK] cells) were assessed in women at high risk for HIV assigned to either tenofovir or placebo gel in the CAPRISA 004 trial. Notwithstanding tenofovir gel use, women who acquired HIV had significantly higher systemic innate immune activation prior to infection than women who remained uninfected. Activation of both soluble (cytokine) and cellular (NK cells) immune mediators were associated with HIV acquisition, individually or in combination. Hence, an innate immune activation suppressant could be added to tenofovir gel as a potential combination gel strategy in developing the next generation of higher efficacy antiretroviral microbicides.en
dc.identifier.citationNaranbhai V., et al. 2012. Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis. 206 (7) pp. 993-1001.en
dc.identifier.issn0022-1899
dc.identifier.urihttp://dx.doi.org/10.1093/infdis/jis465en
dc.identifier.urihttp://hdl.handle.net/10413/9192
dc.language.isoenen
dc.publisherOxford University Press.en
dc.subjectAntiretroviral agents.en
dc.subjectAIDS (Disease) in women--Treatment.en
dc.subjectHIV infections--Immunology.en
dc.subject.otherTenofovir.en
dc.subject.otherAntiretroviral microbicides.en
dc.titleInnate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel.en
dc.typePeer reviewed journal articleen

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