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HIV cell-to-cell spread leads to a differential transcriptional response and slows evolution of drug resistance relative to cell-free infection.

dc.contributor.advisorSigal, Alexander.
dc.contributor.authorHunter, Jessica Rose.
dc.date.accessioned2021-08-24T05:56:00Z
dc.date.available2021-08-24T05:56:00Z
dc.date.created2020
dc.date.issued2020
dc.descriptionDoctoral Degree. University of KwaZulu-Natal, Durban.en_US
dc.description.abstractHIV transmits between hosts but also transmits between cells in the same host. How this latter, cellular transmission occurs has been the subject of extensive study. Yet why HIV transmits between cells using two different infection modes: cell-to-cell spread and cell-free infection, is not clearly understood. This is because cell-to-cell spread is a more efficient mode of infection, where the virus is able to be successfully transmitted between cells despite natural inhibitors such as antibodies. Here, using in vitro experimentation, I have determined some of the implications of cell-to-cell spread of HIV for cell death, evolution, and inflammation. I have discovered potential costs to this infection mode, such as increased cell death, slowed evolution of resistance, and an increased interferon response which may interfere with viral replication. Hence, costs associated with cell-to-cell spread may prevent it being the dominant infection mode in cellular transmission.en_US
dc.identifier.urihttps://researchspace.ukzn.ac.za/handle/10413/19765
dc.language.isoenen_US
dc.subject.otherHIV evolution.en_US
dc.subject.otherCell death.en_US
dc.subject.otherHIV gene expression.en_US
dc.subject.otherHIV infections.en_US
dc.subject.otherHIV (Viruses)en_US
dc.subject.otherDrug resistance.en_US
dc.titleHIV cell-to-cell spread leads to a differential transcriptional response and slows evolution of drug resistance relative to cell-free infection.en_US
dc.typeThesisen_US

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