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Synthesis, characterisation and antibacterial activity of substituted 2-quinoline thiosemicarbazones.

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dc.contributor.advisorKoorbanally, Neil Anthony.
dc.contributor.authorShezi, Siboniso Sibusiso.
dc.date.accessioned2020-04-07T17:26:12Z
dc.date.available2020-04-07T17:26:12Z
dc.date.created2017
dc.date.issued2017
dc.descriptionMasters Degree. University of KwaZulu-Natal, Durban.en_US
dc.description.abstractFifteen quinoline-2-thiosemicarbazone hybrid derivatives were synthesised in a three step reaction involving formation of the quinoline, oxidation of the 2-methyl group and condensation to the thiosemicarbazones. The phenylhydrazines were prepared in an additional step prior to the condensation. Twelve of the fifteen hybrid molecules were novel. A full structural elucidation of all synthesised compounds were carried out using amongst others 1D and 2D NMR spectroscopy and mass spectrometry. The data presented here will provide a basis for the identification of further molecules of this type. The hybrid molecules were then subjected to antibacterial bioassays against Gram -ve and Gram +ve bacterial strains. Unfortunately, only one compound, the 6-bromo-4'-fluoro derivative on the (E)-2-quinoline-2- yl)methylene-N-phenylhydrazinecarbothiamide framework showed any antibacterial activity. They were active against both Staphylococus aureus and methicillin resistant Staphylococcus aureus (MRSA) at 387 uM.en_US
dc.identifier.urihttps://researchspace.ukzn.ac.za/handle/10413/17767
dc.language.isoenen_US
dc.subject.otherQuinoline-2-thiosemicarbazone.en_US
dc.subject.otherAntibacterial.en_US
dc.subject.otherDoebner-von miller.en_US
dc.subject.otherStructural elucidation.en_US
dc.titleSynthesis, characterisation and antibacterial activity of substituted 2-quinoline thiosemicarbazones.en_US
dc.typeThesisen_US

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