Browsing by Author "Garrett, Nigel Joel."

Now showing 1 - 20 of 41

Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoire.
(American Association of Immunologists., 2015) Scheepers, Cathrine.; Shrestha, Ram K.; Lambson, Bronwen Elizabeth.; Jackson, Katherine J. L.; Wright, Imogen A.; Naicker, Dshanta Dyanedi.; Goosen, Mark.; Berrie, Leigh.; Ismail, Arshad.; Garrett, Nigel Joel.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Moore, Penelope L.; Travers, Simon A.; Morris, Lynn.
Abstract available in pdf.
Acceptability of early antiretroviral therapy among South African women.
(Springer., 2018) Garrett, Nigel Joel.; Norman, Emily.; Leask, Kerry.; Naicker, Nivashnee.; Asari, Villeshni.; Majola, Nelisile.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.
Abstract available in pdf.
Advancing STI care in low/middle-income countries : has STI syndromic management reached its use-by date?
(‎BMJ Group., 2017) Garrett, Nigel Joel.; McGrath, Nuala.; Mindel, Adrian.
Abstract available in pdf.
Antibody maturation in women who acquire HIV infection while using antiretroviral pre-exposure prophylaxis.
(Oxford University Press., 2015) Laeyendecker, Oliver.; Redd, Andrew D.; Nason, Martha.; Longosz, Andrew F.; Abdool Karim, Quarraisha.; Naranbhai, Vivek.; Garrett, Nigel Joel.; Eshleman, Susan H.; Abdool Karim, Salim Safurdeen.; Quinn, Thomas C.
Abstract available in pdf.
Beyond syndromic management: opportunities for diagnosis-based treatment of sexually transmitted infections in low- and middle-income countries.
(Public Library of Science., 2018) Garrett, Nigel Joel.; Osman, Farzana.; Maharaj, Bhavna.; Naicker, Nivashnee.; Gibbs, Andrew.; Norman, Emily.; Samsunder, Natasha.; Ngobese, Hope.; Mitchev, Nireshni.; Singh, Ravesh.; Abdool Karim, Salim Safurdeen.; Kharsany, Ayesha Bibi Mahomed.; Mlisana, Koleka Patience.; Rompalo, Anne.; Mindel, Adrian.
Abstract available in pdf.
Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women.
(Wolters Kluwer., 2016) Mkhize, Nonhlanhla N.; Durgiah, Raveshni.; Ashley, Vicki C.; Archary, Derseree.; Garrett, Nigel Joel.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Moore, Penelope L.; Yates, Nicole L.; Passmore, Jo-Ann Shelley.; Tomaras, Georgia D.; Morris, Lynn.
Abstract available in PDF file..
Case report: mechanisms of HIV elite control in two African women.
(BioMed Central., 2018) Moosa, Yumna.; Tanko, Ramla F.; Ramsuran, Veron.; Singh, Ravesh.; Madzivhandila, Mashudu.; Yende-Zuma, Fortunate Nonhlanhla.; Abrahams, Melissa-Rose.; Selhorst, Philippe.; Gounder, Kamini.; Moore, Penelope L.; Williamson, Carolyn.; Abdool Karim, Salim Safurdeen.; Garrett, Nigel Joel.; Burgers, Wendy A.
Abstract available in pdf.
Cervicovaginal inflammation facilitates acquisition of less infectious HIV variants.
(Oxford University Press., 2017) Selhorst, Philippe.; Masson, Lindi.; Ismail, Sherazaan D.; Samsunder, Natasha.; Garrett, Nigel Joel.; Mansoor, Leila Essop.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Passmore, Jo-Ann Shelley.; Williamson, Carolyn.
Abstract available in pdf.
Challenges of diagnosing acute HIV-1 subtype C infection in African women: performance of a clinical algorithm and the need for point-of-care nucleic-acid based testing.
(Plos., 2012) Mlisana, Koleka Patience.; Sobieszczyk, Magdalena E.; Werner, Lise.; Feinstein, Addi.; van Loggerenberg, Francois.; Naicker, Nivashnee.; Williamson, Carolyn.; Garrett, Nigel Joel.
Background. Prompt diagnosis of acute HIV infection (AHI) benefits the individual and provides opportunities for public health intervention. The aim of this study was to describe most common signs and symptoms of AHI, correlate these with early disease progression and develop a clinical algorithm to identify acute HIV cases in resource limited setting. Methods. 245 South African women at high-risk of HIV-1 were assessed for AHI and received monthly HIV-1 antibody and RNA testing. Signs and symptoms at first HIV-positive visit were compared to HIV-negative visits. Logistic regression identified clinical predictors of AHI. A model-based score was assigned to each predictor to create a risk score for every woman. Results. Twenty-eight women seroconverted after a total of 390 person-years of follow-up with an HIV incidence of 7.2/100 person-years (95%CI 4.5–9.8). Fifty-seven percent reported ≥1 sign or symptom at the AHI visit. Factors predictive of AHI included age <25 years (OR = 3.2; 1.4–7.1), rash (OR = 6.1; 2.4–15.4), sore throat (OR = 2.7; 1.0–7.6), weight loss (OR = 4.4; 1.5–13.4), genital ulcers (OR = 8.0; 1.6–39.5) and vaginal discharge (OR = 5.4; 1.6–18.4). A risk score of 2 correctly predicted AHI in 50.0% of cases. The number of signs and symptoms correlated with higher HIV-1 RNA at diagnosis (r = 0.63; p<0.001). Conclusions. Accurate recognition of signs and symptoms of AHI is critical for early diagnosis of HIV infection. Our algorithm may assist in risk-stratifying individuals for AHI, especially in resource-limited settings where there is no routine testing for AHI. Independent validation of the algorithm on another cohort is needed to assess its utility further. Point-of-care antigen or viral load technology is required, however, to detect asymptomatic, antibody negative cases enabling early interventions and prevention of transmission.
Clinic flow for STI, HIV, and TB patients in an urban infectious disease clinic offering point-of-care testing services in Durban, South Africa.
(BioMed Central., 2018) Stime, Katrina J.; Garrett, Nigel Joel.; Sookrajh, Yukteshwar.; Dorward, Jienchi.; Dlamini, Ntuthu.; Olowolagba, Ayo.; Sharma, Monisha.; Barnabas, Ruanne V.; Drain, Paul K.
Abstract available in pdf.
Computational analysis of antibody dynamics identifies recent HIV-1 infection.
(American Society for Clinical Investigation., 2017) Seaton, Kelly E.; Vandergrift, Nathan A.; Deal, Aaron W.; Rountree, Wes.; Bainbridge, John.; Grebe, Eduard.; Anderson, David A.; Sawant, Sheetal.; Shen, Xiaoying.; Yates, Nicole L.; Denny, Thomas N.; Liao, Hua-Xin.; Haynes, Barton F.; Robb, Merlin L.; Parkin, Neil.; Santos, Breno R.; Garrett, Nigel Joel.; Price, Matthew A.; Naniche, Denise.; Duerr, Ann C.; Keating, Sheila.; Hampton, Dylan.; Facente, Shelley.; Marson, Kara.; Welte, Alex.; Pilcher, Christopher D.; Cohen, Myron S.; Tomaras, Georgia D.
Abstract available in pdf.
Cooperation between strain-specific and broadly neutralizing responses limited viral escape and prolonged the exposure of the broadly neutralizing epitope.
(American Society for Microbiology., 2017) Anthony, Colin S.; York, Talita.; Bekker, Valerie.; Matten, David.; Selhorst, Philippe.; Ferreria, Roux-Cil.; Garrett, Nigel Joel.; Abdool Karim, Salim Safurdeen.; Morris, Lynn.; Wood, Natasha T.; Moore, Penelope L.; Williamson, Carolyn.
Abstract available in pdf.
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
(Macmillan Publishers Limited., 2014) Doria-Rose, Nicole A.; Schramm, Chaim A.; Gorman, Jason.; Moore, Penelope L.; Bhiman, Jinal N.; DeKosky, Brandon J.; Ernandes, Michael J.; Georgiev, Ivelin S.; Kim, Helen J.; Pancera, Marie.; Staupe, Ryan P.; Altae-Tran, Han R.; Bailer, Robert T.; Crooks, Ema T.; Druz, Aliaksandr.; Garrett, Nigel Joel.; Hoi, Kam H.; Kong, Rui.; Louder, Mark K.; Longo, Nancy S.; McKee, Krisha.; Nonyane, Molati.; O’Dell, Sijy.; Roark, Ryan S.; Rudicell, Rebecca S.; Schmidt, Stephen D.; Sheward, Daniel J.; Soto, Cinque.; Wibmer, Constantinos Kurt.; Yang, Yongping.; Zhang, Zhenhai.; Mullikin, James C.; Binley, James M.; Sanders, Rogier W.; Wilson, Ian A.; Moore, John P.; Ward, Andrew B.; Georgiou, George.; Williamson, Carolyn.; Abdool Karim, Salim Safurdeen.; Morris, Lynn.; Kwong, Peter D.; Shapiro, Lawrence.; Mascola, John R.
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the developmental pathway by which such antibodies are generated and acquire the requisite molecular characteristics for neutralization. Twelve somatically related neutralizing antibodies (CAP256-VRC26.01-12) were isolated from donor CAP256 (from the Centre for the AIDS Programme of Research in South Africa (CAPRISA)); each antibody contained the protruding tyrosine-sulphated, anionic antigen-binding loop (complementarity-determining region (CDR) H3) characteristic of this category of antibodies. Their unmutated ancestor emerged between weeks 30-38 post-infection with a 35-residue CDR H3, and neutralized the virus that superinfected this individual 15 weeks after initial infection. Improved neutralization breadth and potency occurred by week 59 with modest affinity maturation, and was preceded by extensive diversification of the virus population. HIV-1 V1V2-directed neutralizing antibodies can thus develop relatively rapidly through initial selection of B cells with a long CDR H3, and limited subsequent somatic hypermutation. These data provide important insights relevant to HIV-1 vaccine development.
Diagnostic accuracy of the Xpert CT/NG and OSOM Trichomonas Rapid assays for point-of-care STI testing among young women in South Africa: a cross-sectional study.
(BMJ Publishing Group., 2019) Osman, Farzana.; Naidoo, Jessica.; Dorward, Jienchi.; Singh, Ravesh.; Ngobese, Hope.; Rompalo, Anne.; Mindel, Adrian.; Garrett, Nigel Joel.; Mlisana, Koleka Patience.
Abstract available in PDF.
Distinct genital tract HIV-specific antibody profiles associated with Tenofovir gel.
(Nature., 2016) Archary, Derseree.; Seaton, Kelly E.; Passmore, Jo-Ann Shelley.; Werner, Lise.; Deal, Aaron W.; Dunphy, Laura J.; Arnold, Kelly B.; Yates, Nicole L.; Lauffenburger, Douglas A.; Bergin, Philip.; Liebenberg, Lenine Julie.; Samsunder, Natasha.; Mureithi, Marianne W.; Altfeld, Marcus.; Garrett, Nigel Joel.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Morris, Lynn.; Tomaras, Georgia D.
Abstract available in PDF file.
Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research.
(Elsevier., 2018) Dorward, Jienchi.; Lessells, Richard John.; Drain, Paul K.; Naidoo, Kogieleum.; De Oliveira, Tulio De Paiva Nazareth Andrade.; Pillay, Yogan.; Abdool Karim, Salim Safurdeen.; Garrett, Nigel Joel.
Abstract available in pdf.
Early evolution of HLA-associated escape mutations in variable Gag proteins predicts CD4+ decline in HIV-1 subtype C infected women.
(Wolters Kluwer Health., 2017) Chopera, Denis Rutendo.; Ntale, Roman.; Ndabambi, Nonkululeko.; Garrett, Nigel Joel.; Gray, Clive M.; Matten, David.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.
Abstract available in pdf.
Effect of antiretroviral therapy on the memory and activation profiles of B cells in HIV-infected African women.
(American Association of Immunologists., 2017) Tanko, Ramla F.; Soares, Andreia P.; Müller, Tracey L.; Garrett, Nigel Joel.; Samsunder, Natasha.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Riou, Catherine.; Burgers, Wendy A.
Abstract available in pdf.
Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes.
(Wolters Kluwer Health., 2016) Reddy, Kavidha.; Ooms, Marcel.; Letko, Michael.; Garrett, Nigel Joel.; Simon, Viviana.; Ndung'u, Peter Thumbi.
Abstract available in PDF file.
Genital inflammation and the risk of HIV acquisition in women.
(Oxford University Press., 2015) Masson, Lindi.; Passmore, Jo-Ann Shelley.; Liebenberg, Lenine Julie.; Werner, Lise.; Baxter, Cheryl.; Arnold, Kelly B.; Williamson, Carolyn.; Little, Francesca.; Mansoor, Leila Essop.; Naranbhai, Vivek.; Lauffenburger, Douglas A.; Ronacher, Katharina.; Walzl, Gerhard.; Garrett, Nigel Joel.; Williams, Brent L.; Couto-Rodriguez, Mara.; Hornig, Mady.; Lipkin, Walter Ian.; Grobler, Anna Christina.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.
Abstract available in pdf.